Metformin and Hepatic function abnormal - a phase IV clinical study of FDA data

Summary:

Hepatic function abnormal is reported as a side effect among people who take Metformin (metformin hydrochloride), especially for people who are male, 60+ old, have been taking the drug for 1 - 6 months also take Aspirin, and have High blood pressure.

The phase IV clinical study analyzes which people have Hepatic function abnormal when taking Metformin. It is created by eHealthMe based on reports of 453,860 people who have side effects when taking Metformin from the FDA, and is updated regularly.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,269 Metformin users. Check the latest studies of Metformin.

What is Hepatic function abnormal?

Hepatic function abnormal is found to be associated with 1,490 drugs and 2,008 conditions by eHealthMe. Check the latest studies of Hepatic function abnormal.

On Sep, 19, 2025

453,860 people reported to have side effects when taking Metformin.
Among them, 628 people (0.14%) have Hepatic function abnormal.

Could Metformin cause Hepatic function abnormal?

Among these 628 people:

How long have people been on Metformin when they have Hepatic function abnormal? *

What is the gender of people who have Hepatic function abnormal when taking Metformin? *

female: 38.58 %
male: 61.42 %

What is the age of people who have Hepatic function abnormal when taking Metformin? *

What are other drugs people take besides Metformin? *

What are other side effects people have besides Hepatic function abnormal? *

Renal Impairment (severely reduced kidney function): 132 people, 21.02%
Fever: 91 people, 14.49%
Acute Kidney Failure: 78 people, 12.42%
Weakness: 70 people, 11.15%
Hyperkalemia (damage to or disease of the kidney): 57 people, 9.08%
Alanine Aminotransferase Increased: 55 people, 8.76%
High Blood Pressure: 51 people, 8.12%
Lactic Acidosis (low ph in body tissues): 49 people, 7.80%
Malaise (a feeling of general discomfort or uneasiness): 48 people, 7.64%
Abdominal Pain: 47 people, 7.48%

What are the existing conditions these people have? *

High Blood Pressure: 96 people, 15.29%
High Blood Cholesterol: 37 people, 5.89%
Dyslipidaemia (abnormal amount of lipids): 25 people, 3.98%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 20 people, 3.18%
Hepatocellular Carcinoma (liver cancer): 19 people, 3.03%
Depression: 16 people, 2.55%
Hyperlipidaemia (presence of excess lipids in the blood): 16 people, 2.55%
Constipation: 15 people, 2.39%
Fever: 14 people, 2.23%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 14 people, 2.23%

* Approximation only. Some reports may have incomplete information.

Do you take Metformin and have Hepatic function abnormal?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Metformin:

Metformin (465,269 reports)

Hepatic function abnormal treatments and more:

Hepatic function abnormal (47,051 reports)

How severe was Hepatic function abnormal and when was it recovered:

Hepatic function abnormal in Metformin

Browse all side effects of Metformin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride (the active ingredients of Metformin) and Metformin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.