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Metformin and Infusion site urticaria - a phase IV clinical study of FDA data

Summary:

Infusion site urticaria is reported as a side effect among people who take Metformin (metformin hydrochloride), especially for people who are female, 60+ old, also take Epinephrine, and have Immunodeficiency common variable.

The phase IV clinical study analyzes which people have Infusion site urticaria when taking Metformin. It is created by eHealthMe based on reports of 453,860 people who have side effects when taking Metformin from the FDA, and is updated regularly.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,354 Metformin users. Check the latest studies of Metformin.

What is Infusion site urticaria?

Infusion site urticaria (rash of round, red welts on the skin at infusion site) is found to be associated with 180 drugs and 89 conditions by eHealthMe. Check the latest studies of Infusion site urticaria.

On Jul, 07, 2026

453,860 people reported to have side effects when taking Metformin.
Among them, 32 people (0.01%) have Infusion site urticaria.

Could Metformin cause Infusion site urticaria?

Among these 32 people:

What is the gender of people who have Infusion site urticaria when taking Metformin? *

  • female: 96.88 %
  • male: 3.12 %

What is the age of people who have Infusion site urticaria when taking Metformin? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 6.25 %
  • 40-49: 37.5 %
  • 50-59: 0.0 %
  • 60+: 56.25 %

What are other drugs people take besides Metformin? *

  1. Epinephrine: 24 people, 75.00%
  2. Acetaminophen: 21 people, 65.62%
  3. Magnesium: 14 people, 43.75%
  4. Omeprazole: 14 people, 43.75%
  5. Lidocaine: 13 people, 40.62%
  6. Losartan Potassium: 11 people, 34.38%
  7. Furosemide: 10 people, 31.25%
  8. Folic Acid: 10 people, 31.25%
  9. Singulair: 10 people, 31.25%
  10. Ondansetron: 10 people, 31.25%

What are other side effects people have besides Infusion site urticaria? *

  1. Infusion Site Erythema (reddening of the skin at infusion site): 14 people, 43.75%
  2. Itching: 12 people, 37.50%
  3. Sinusitis (inflammation of sinus): 12 people, 37.50%
  4. Rashes (redness): 11 people, 34.38%
  5. Infusion Site Haemorrhage (bleeding from infusion site): 11 people, 34.38%
  6. Localised Infection (infection at the single location): 11 people, 34.38%
  7. Infection: 10 people, 31.25%
  8. Weight Decreased: 10 people, 31.25%
  9. Infusion Site Pruritus (severe itching at infusion site): 10 people, 31.25%
  10. Upper Respiratory Tract Infection: 10 people, 31.25%

What are the existing conditions these people have? *

  1. Immunodeficiency Common Variable: 27 people, 84.38%
  2. Fever: 6 people, 18.75%
  3. Nausea (feeling of having an urge to vomit): 4 people, 12.50%
  4. Hypergammaglobulinaemia (elevated levels of gamma globulin): 2 people, 6.25%
  5. Weakness: 1 person, 3.12%
  6. Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 1 person, 3.12%

* Approximation only. Some reports may have incomplete information.

Do you take Metformin and have Infusion site urticaria?

- Check whether Infusion site urticaria is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Metformin:

Infusion site urticaria treatments and more:

How severe was Infusion site urticaria and when was it recovered:

Expand to all the drugs that have ingredients of metformin hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Metformin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Infusion site urticaria:

Browse all the conditions that are associated with Infusion site urticaria:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride (the active ingredients of Metformin) and Metformin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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