Metformin and Ipf - a phase IV clinical study of FDA data

Summary:

Ipf is reported as a side effect among people who take Metformin (metformin hydrochloride), especially for people who are male, 60+ old, have been taking the drug for 5 - 10 years also take Prednisone, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Ipf when taking Metformin. It is created by eHealthMe based on reports of 453,860 people who have side effects when taking Metformin from the FDA, and is updated regularly.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,321 Metformin users. Check the latest studies of Metformin.

What is Ipf?

Ipf is found to be associated with 1,845 drugs and 2,253 conditions by eHealthMe. Check the latest studies of Ipf.

On Jan, 10, 2026

453,860 people reported to have side effects when taking Metformin.
Among them, 1,005 people (0.22%) have Ipf.

Among these 1,005 people:

* Approximation only. Some reports may have incomplete information.

Do you take Metformin and have Ipf?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Metformin:

Metformin (465,321 reports)

Ipf treatments and more:

Ipf (79,192 reports)

How severe was Ipf and when was it recovered:

Ipf in Metformin

Expand to all the drugs that have ingredients of metformin hydrochloride:

Ipf and drugs with ingredients of metformin hydrochloride (1,134 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Common Metformin side effects:

Browse all side effects of Metformin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Ipf:

Methotrexate side effect: Ipf (4,714 reports)
Prednisone side effect: Ipf (4,117 reports)
Humira side effect: Ipf (2,869 reports)
Enbrel side effect: Ipf (2,842 reports)
Ofev side effect: Ipf (2,063 reports)
Remicade side effect: Ipf (2,043 reports)
Actemra side effect: Ipf (2,024 reports)
Leflunomide side effect: Ipf (1,957 reports)
Xeljanz side effect: Ipf (1,940 reports)
Pantoprazole side effect: Ipf (1,758 reports)

Browse all the drugs that are associated with Ipf:

Ipf (1,845 drugs)

Common conditions associated with Ipf:

Ra: 5,843 reports
Ipf: 2,256 reports
Atrial fibrillation/flutter: 1,089 reports
Hypertension aggravated: 1,023 reports
Blood pressure increased: 1,015 reports
Psoriatic arthropathy: 851 reports
Idiopathic pulmonary fibrosis: 843 reports
Primary pulmonary hypertension: 793 reports
Psoriasis: 789 reports
Osteoporosis: 682 reports

Browse all the conditions that are associated with Ipf:

Ipf (2,253 conditions)

Drugs similar to Metformin and Ipf :

Related publications that referenced our studies

T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito, "Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?", Case Reports in Endocrinology, 2018 Jan .
Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .
Wiwanitkit S, Wiwanitkit V, "Metformin and sleep disorders", Indian journal of endocrinology and metabolism, 2012 Jan .
T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito, "Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?", Case Reports in Endocrinology, 2018 Jan .
Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .
Wiwanitkit S, Wiwanitkit V, "Metformin and sleep disorders", Indian journal of endocrinology and metabolism, 2012 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride (the active ingredients of Metformin) and Metformin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.