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Metformin and Nail abnormalities - a phase IV clinical study of FDA data

Summary:

Nail abnormalities is reported as a side effect among people who take Metformin (metformin hydrochloride), especially for people who are male, 60+ old, also take Lyrica, and have Psoriasis.

The phase IV clinical study analyzes which people have Nail abnormalities when taking Metformin. It is created by eHealthMe based on reports of 453,860 people who have side effects when taking Metformin from the FDA, and is updated regularly.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,354 Metformin users. Check the latest studies of Metformin.

What is Nail abnormalities?

Nail abnormalities (abnormal nail) is found to be associated with 211 drugs and 651 conditions by eHealthMe. Check the latest studies of Nail abnormalities.

On Jul, 09, 2026

453,860 people reported to have side effects when taking Metformin.
Among them, 46 people (0.01%) have Nail abnormalities.

Could Metformin cause Nail abnormalities?

Among these 46 people:

What is the gender of people who have Nail abnormalities when taking Metformin? *

  • female: 41.86 %
  • male: 58.14 %

What is the age of people who have Nail abnormalities when taking Metformin? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 4.55 %
  • 40-49: 22.73 %
  • 50-59: 18.18 %
  • 60+: 54.55 %

What are other drugs people take besides Metformin? *

  1. Lyrica: 10 people, 21.74%
  2. Cosentyx: 9 people, 19.57%
  3. Humira: 7 people, 15.22%
  4. Methotrexate: 6 people, 13.04%
  5. Aspirin: 6 people, 13.04%
  6. Escitalopram: 4 people, 8.70%
  7. Fish Oil: 4 people, 8.70%
  8. Tylenol: 4 people, 8.70%
  9. Triamcinolone: 4 people, 8.70%
  10. Lantus: 3 people, 6.52%

What are other side effects people have besides Nail abnormalities? *

  1. Rashes (redness): 20 people, 43.48%
  2. Blood Glucose Increased: 14 people, 30.43%
  3. Cardiac Failure: 14 people, 30.43%
  4. Diarrhea: 14 people, 30.43%
  5. Psoriasis (immune-mediated disease that affects the skin): 14 people, 30.43%
  6. Fluid Retention (an abnormal accumulation of fluid in the blood): 13 people, 28.26%
  7. Pain In Extremity: 13 people, 28.26%
  8. Abdominal Discomfort: 12 people, 26.09%
  9. Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 12 people, 26.09%
  10. Pneumonia: 12 people, 26.09%

What are the existing conditions these people have? *

  1. Psoriasis (immune-mediated disease that affects the skin): 14 people, 30.43%
  2. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 8 people, 17.39%
  3. Cellulitis (infection under the skin): 3 people, 6.52%
  4. Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 2 people, 4.35%
  5. Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 2 people, 4.35%
  6. Breast Cancer Metastatic: 2 people, 4.35%
  7. Thyroid Diseases: 1 person, 2.17%
  8. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 2.17%
  9. Prostate Cancer Metastatic: 1 person, 2.17%
  10. Lung Neoplasm Malignant (cancer tumour of lung): 1 person, 2.17%

* Approximation only. Some reports may have incomplete information.

Do you take Metformin and have Nail abnormalities?

- Check whether Nail abnormalities is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Metformin:

Nail abnormalities treatments and more:

How severe was Nail abnormalities and when was it recovered:

Expand to all the drugs that have ingredients of metformin hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Metformin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Nail abnormalities:

Browse all the conditions that are associated with Nail abnormalities:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride (the active ingredients of Metformin) and Metformin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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