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Metformin and Relapsing fever - a phase IV clinical study of FDA data

Summary:

Relapsing fever is reported as a side effect among people who take Metformin (metformin hydrochloride), especially for people who are female, 40-49 old, also take Levaquin, and have Bipolar disorder.

The phase IV clinical study analyzes which people have Relapsing fever when taking Metformin. It is created by eHealthMe based on reports of 453,860 people who have side effects when taking Metformin from the FDA, and is updated regularly.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,355 Metformin users. Check the latest studies of Metformin.

What is Relapsing fever?

Relapsing fever (bacterial infection characterized by recurring episodes of fever, headache, muscle and joint aches, and nausea) is found to be associated with 57 drugs and 274 conditions by eHealthMe. Check the latest studies of Relapsing fever.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 29, 2026

453,860 people reported to have side effects when taking Metformin.
Among them, 12 people (0.0%) have Relapsing fever.

Could Metformin cause Relapsing fever?

Among these 12 people:

What is the gender of people who have Relapsing fever when taking Metformin? *

  • female: 75 %
  • male: 25 %

What is the age of people who have Relapsing fever when taking Metformin? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 75.0 %
  • 50-59: 8.33 %
  • 60+: 16.67 %

What are other drugs people take besides Metformin? *

  1. Prilosec: 7 people, 58.33%
  2. Promethazine W/ Codeine: 7 people, 58.33%
  3. Glimepiride: 7 people, 58.33%
  4. Guaifenesin: 7 people, 58.33%
  5. Famotidine: 7 people, 58.33%
  6. Hydrochlorothiazide: 7 people, 58.33%
  7. Diovan: 7 people, 58.33%
  8. Ibuprofen: 7 people, 58.33%
  9. Zoloft: 7 people, 58.33%
  10. Levaquin: 7 people, 58.33%

What are other side effects people have besides Relapsing fever? *

  1. High Blood Cholesterol: 8 people, 66.67%
  2. Wheezing (a high-pitched whistling sound made while you breath): 7 people, 58.33%
  3. Metastasis (spreadable cancer to other organ from origin): 7 people, 58.33%
  4. Joint Pain: 7 people, 58.33%
  5. Infectious Mononucleosis (infection usually caused by the epstein-barr virus): 7 people, 58.33%
  6. Hypoglycemia (low blood sugar): 7 people, 58.33%
  7. Hyperthyroidism (over activity of the thyroid gland): 7 people, 58.33%
  8. Weight Loss: 7 people, 58.33%
  9. Hyperhidrosis (abnormally increased sweating): 7 people, 58.33%
  10. Herpes Simplex (herpes simplex is a common viral infection): 7 people, 58.33%

What are the existing conditions these people have? *

  1. Stress And Anxiety: 7 people, 58.33%
  2. Depression: 7 people, 58.33%
  3. Bipolar Disorder (mood disorder): 7 people, 58.33%
  4. Sleep Disorder: 6 people, 50.00%
  5. Anger: 5 people, 41.67%
  6. Psoriasis (immune-mediated disease that affects the skin): 3 people, 25.00%
  7. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 16.67%
  8. High Blood Cholesterol: 2 people, 16.67%
  9. Pain: 1 person, 8.33%
  10. High Blood Pressure: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Metformin and have Relapsing fever?

- Check whether Relapsing fever is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Metformin:

Relapsing fever treatments and more:

How severe was Relapsing fever and when was it recovered:

Expand to all the drugs that have ingredients of metformin hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Metformin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Relapsing fever:

Browse all the conditions that are associated with Relapsing fever:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride (the active ingredients of Metformin) and Metformin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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