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Metformin and Seizure like phenomena - a phase IV clinical study of FDA data

Summary:

Seizure like phenomena is reported as a side effect among people who take Metformin (metformin hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Advair Hfa, and have Parkinson's disease.

The phase IV clinical study analyzes which people have Seizure like phenomena when taking Metformin. It is created by eHealthMe based on reports of 453,860 people who have side effects when taking Metformin from the FDA, and is updated regularly.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,344 Metformin users. Check the latest studies of Metformin.

What is Seizure like phenomena?

Seizure like phenomena (a variety of medical conditions may produce sudden episodes which have some similarities to epileptic seizures) is found to be associated with 214 drugs and 341 conditions by eHealthMe. Check the latest studies of Seizure like phenomena.

On Mar, 11, 2026

453,860 people reported to have side effects when taking Metformin.
Among them, 36 people (0.01%) have Seizure like phenomena.

Could Metformin cause Seizure like phenomena?

Among these 36 people:

How long have people been on Metformin when they have Seizure like phenomena? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 100 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Seizure like phenomena when taking Metformin? *

  • female: 67.65 %
  • male: 32.35 %

What is the age of people who have Seizure like phenomena when taking Metformin? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 14.29 %
  • 60+: 85.71 %

What are other drugs people take besides Metformin? *

  1. Advair Hfa: 7 people, 19.44%
  2. Novolog: 5 people, 13.89%
  3. Lantus: 5 people, 13.89%
  4. Xyrem: 5 people, 13.89%
  5. Singulair: 5 people, 13.89%
  6. Lyrica: 4 people, 11.11%
  7. Requip: 4 people, 11.11%
  8. Savella: 4 people, 11.11%
  9. Cymbalta: 4 people, 11.11%
  10. Nuplazid: 3 people, 8.33%

What are other side effects people have besides Seizure like phenomena? *

  1. Hypotension (abnormally low blood pressure): 9 people, 25.00%
  2. Renal Impairment (severely reduced kidney function): 9 people, 25.00%
  3. Overdose: 8 people, 22.22%
  4. Lactic Acidosis (low ph in body tissues): 8 people, 22.22%
  5. Pain: 7 people, 19.44%
  6. Agitation (state of anxiety or nervous excitement): 5 people, 13.89%
  7. Drug Ineffective: 5 people, 13.89%
  8. Gait Disturbance: 5 people, 13.89%
  9. Dehydration (dryness resulting from the removal of water): 5 people, 13.89%
  10. Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 5 people, 13.89%

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 13.89%
  2. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 13.89%
  3. Parkinson's Disease: 5 people, 13.89%
  4. Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 4 people, 11.11%
  5. Fibromyalgia (a long-term condition which causes pain all over the body): 4 people, 11.11%
  6. High Blood Pressure: 4 people, 11.11%
  7. Rashes (redness): 3 people, 8.33%
  8. Pain: 3 people, 8.33%
  9. High Blood Cholesterol: 3 people, 8.33%
  10. Wheezing (a high-pitched whistling sound made while you breath): 2 people, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Metformin and have Seizure like phenomena?

- Check whether Seizure like phenomena is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Metformin:

Seizure like phenomena treatments and more:

How severe was Seizure like phenomena and when was it recovered:

Expand to all the drugs that have ingredients of metformin hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Metformin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Seizure like phenomena:

Browse all the conditions that are associated with Seizure like phenomena:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride (the active ingredients of Metformin) and Metformin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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