Metformin and Stroke - a phase IV clinical study of FDA data


Stroke is found among people who take Metformin, especially for people who are female, 60+ old, have been taking the drug for < 1 month.

The phase IV clinical study analyzes which people take Metformin and have Stroke. It is created by eHealthMe based on reports of 429,842 people who have side effects when taking Metformin from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 12, 2023

429,842 people reported to have side effects when taking Metformin.
Among them, 5,457 people (1.27%) have Stroke.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 406,473 Metformin users for its effectiveness, alternative drugs and more.

What is Stroke?

Stroke (sudden death of a portion of the brain cells due to a lack of oxygen) is found to be associated with 3,638 drugs and 2,976 conditions by eHealthMe.

Number of Metformin and Stroke reports submitted per year:

Could Metformin cause Stroke?

Time on Metformin when people have Stroke *:

Click here to view

Gender of people who have Stroke when taking Metformin*:

Click here to view

Age of people who have Stroke when taking Metformin *:

Click here to view

Common drugs people take besides Metformin *:

Click here to view

Common side effects people have besides Stroke *:

Click here to view

Common conditions people have *:

Click here to view

* Approximation only. Some reports may have incomplete information.

Do you take Metformin and have Stroke?

Check whether Stroke is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

How severe was Stroke and when was it recovered:

Expand to all the drugs that have ingredients of metformin hydrochloride:

Alternative drugs to, pros and cons of Metformin:

Common Metformin side effects:

Browse all side effects of Metformin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Stroke treatments and more:

COVID vaccines that are related to Stroke:

Common drugs associated with Stroke:

All the drugs that are associated with Stroke:

Common conditions associated with Stroke:

All the conditions that are associated with Stroke:

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride (the active ingredients of Metformin) and Metformin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe: