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Metformin and Thyroid function test abnormal - a phase IV clinical study of FDA data

Summary:

Thyroid function test abnormal is reported as a side effect among people who take Metformin (metformin hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Synthroid, and have High blood pressure.

The phase IV clinical study analyzes which people have Thyroid function test abnormal when taking Metformin. It is created by eHealthMe based on reports of 453,860 people who have side effects when taking Metformin from the FDA, and is updated regularly.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,291 Metformin users. Check the latest studies of Metformin.

What is Thyroid function test abnormal?

Thyroid function test abnormal is found to be associated with 1,705 drugs and 1,582 conditions by eHealthMe. Check the latest studies of Thyroid function test abnormal.

On Sep, 01, 2025

453,860 people reported to have side effects when taking Metformin.
Among them, 685 people (0.15%) have Thyroid function test abnormal.

Could Metformin cause Thyroid function test abnormal?

Among these 685 people:

How long have people been on Metformin when they have Thyroid function test abnormal? *

  • < 1 month: 54.55 %
  • 1 - 6 months: 27.27 %
  • 6 - 12 months: 9.09 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 9.09 %

What is the gender of people who have Thyroid function test abnormal when taking Metformin? *

  • female: 70.86 %
  • male: 29.14 %

What is the age of people who have Thyroid function test abnormal when taking Metformin? *

  • 0-1: 0.2 %
  • 2-9: 0.0 %
  • 10-19: 1.42 %
  • 20-29: 2.03 %
  • 30-39: 2.84 %
  • 40-49: 11.76 %
  • 50-59: 20.28 %
  • 60+: 61.46 %

What are other drugs people take besides Metformin? *

  1. Synthroid: 98 people, 14.31%
  2. Aspirin: 66 people, 9.64%
  3. Lipitor: 57 people, 8.32%
  4. Omeprazole: 50 people, 7.30%
  5. Crestor: 47 people, 6.86%
  6. Lisinopril: 46 people, 6.72%
  7. Lantus: 45 people, 6.57%
  8. Amlodipine: 45 people, 6.57%
  9. Januvia: 40 people, 5.84%
  10. Vitamin D: 38 people, 5.55%

What are other side effects people have besides Thyroid function test abnormal? *

  1. High Blood Pressure: 157 people, 22.92%
  2. Weight Decreased: 136 people, 19.85%
  3. Fatigue (feeling of tiredness): 130 people, 18.98%
  4. Pain: 109 people, 15.91%
  5. Nausea (feeling of having an urge to vomit): 99 people, 14.45%
  6. Dyspnea (difficult or laboured breathing): 98 people, 14.31%
  7. Headache (pain in head): 97 people, 14.16%
  8. Joint Pain: 95 people, 13.87%
  9. Blood Glucose Increased: 87 people, 12.70%
  10. Stress And Anxiety: 82 people, 11.97%

What are the existing conditions these people have? *

  1. High Blood Pressure: 109 people, 15.91%
  2. High Blood Cholesterol: 78 people, 11.39%
  3. Depression: 61 people, 8.91%
  4. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 51 people, 7.45%
  5. Sleep Disorder: 36 people, 5.26%
  6. Acromegaly (body produces too much growth hormone, leading to excess growth of body tissues): 36 people, 5.26%
  7. Stress And Anxiety: 32 people, 4.67%
  8. Psoriasis (immune-mediated disease that affects the skin): 31 people, 4.53%
  9. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 30 people, 4.38%
  10. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 27 people, 3.94%

* Approximation only. Some reports may have incomplete information.

Do you take Metformin and have Thyroid function test abnormal?

- Check whether Thyroid function test abnormal is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Metformin:

Thyroid function test abnormal treatments and more:

How severe was Thyroid function test abnormal and when was it recovered:

Expand to all the drugs that have ingredients of metformin hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Common Metformin side effects:

Browse all side effects of Metformin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Thyroid function test abnormal:

Browse all the drugs that are associated with Thyroid function test abnormal:

Common conditions associated with Thyroid function test abnormal:

Browse all the conditions that are associated with Thyroid function test abnormal:

Drugs similar to Metformin and Thyroid function test abnormal :

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride (the active ingredients of Metformin) and Metformin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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