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Metformin and Thyroxine decreased - a phase IV clinical study of FDA data

Summary:

Thyroxine decreased is reported as a side effect among people who take Metformin (metformin hydrochloride), especially for people who are male, 50-59 old, have been taking the drug for 2 - 5 years also take Diovan, and have High blood pressure.

The phase IV clinical study analyzes which people have Thyroxine decreased when taking Metformin. It is created by eHealthMe based on reports of 453,860 people who have side effects when taking Metformin from the FDA, and is updated regularly.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,354 Metformin users. Check the latest studies of Metformin.

What is Thyroxine decreased?

Thyroxine decreased is found to be associated with 135 drugs and 244 conditions by eHealthMe. Check the latest studies of Thyroxine decreased.

On Jul, 29, 2026

453,860 people reported to have side effects when taking Metformin.
Among them, 15 people (0.0%) have Thyroxine decreased.

Could Metformin cause Thyroxine decreased?

Among these 15 people:

How long have people been on Metformin when they have Thyroxine decreased? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 100 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Thyroxine decreased when taking Metformin? *

  • female: 50 %
  • male: 50 %

What is the age of people who have Thyroxine decreased when taking Metformin? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 7.69 %
  • 40-49: 7.69 %
  • 50-59: 46.15 %
  • 60+: 38.46 %

What are other drugs people take besides Metformin? *

  1. Vitamin D: 2 people, 13.33%
  2. Allopurinol: 2 people, 13.33%
  3. Hydroxyurea: 2 people, 13.33%
  4. Tasigna: 2 people, 13.33%
  5. Synthroid: 2 people, 13.33%
  6. Armour Thyroid: 2 people, 13.33%
  7. Januvia: 2 people, 13.33%
  8. Diovan: 2 people, 13.33%
  9. Xanax: 1 person, 6.67%
  10. Cetirizine Hydrochloride: 1 person, 6.67%

What are other side effects people have besides Thyroxine decreased? *

  1. Blood Thyroid Stimulating Hormone Increased: 7 people, 46.67%
  2. Blood Thyroid Stimulating Hormone Decreased: 6 people, 40.00%
  3. Thyroid Diseases: 6 people, 40.00%
  4. Tri-Iodothyronine Decreased: 5 people, 33.33%
  5. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 33.33%
  6. Blood Glucose Increased: 3 people, 20.00%
  7. Hyperglycemia (high blood sugar): 3 people, 20.00%
  8. High Blood Pressure: 3 people, 20.00%
  9. Heart Rate Increased: 3 people, 20.00%
  10. Fatigue (feeling of tiredness): 3 people, 20.00%

What are the existing conditions these people have? *

  1. High Blood Pressure: 4 people, 26.67%
  2. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 13.33%
  3. Hyperuricaemia (level of uric acid in the blood that is abnormally high): 2 people, 13.33%
  4. Hypopituitarism (diminished hormone secretion by the pituitary gland, causing dwarfism in children and premature aging in adults): 2 people, 13.33%
  5. Polycythemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 2 people, 13.33%
  6. Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 2 people, 13.33%
  7. Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 2 people, 13.33%
  8. Embolism Venous (embolus may pass into the arterial system): 2 people, 13.33%
  9. Diabetes Insipidus (diabetes caused by a deficiency of the pituitary hormone vasopressin, which regulates kidney function): 1 person, 6.67%
  10. Glucose Tolerance Impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Metformin and have Thyroxine decreased?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Metformin:

Thyroxine decreased treatments and more:

How severe was Thyroxine decreased and when was it recovered:

Expand to all the drugs that have ingredients of metformin hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Metformin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Thyroxine decreased:

Browse all the conditions that are associated with Thyroxine decreased:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride (the active ingredients of Metformin) and Metformin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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