Methotrexate and Differential white blood cell count abnormal - a phase IV clinical study of FDA data

Summary:

Differential white blood cell count abnormal is reported as a side effect among people who take Methotrexate (methotrexate sodium), especially for people who are female, 60+ old, have been taking the drug for 5 - 10 years also take Folic Acid, and have Dyspnea.

The phase IV clinical study analyzes which people have Differential white blood cell count abnormal when taking Methotrexate. It is created by eHealthMe based on reports of 599,650 people who have side effects when taking Methotrexate from the FDA, and is updated regularly.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,313 Methotrexate users. Check the latest studies of Methotrexate.

What is Differential white blood cell count abnormal?

Differential white blood cell count abnormal is found to be associated with 89 drugs and 290 conditions by eHealthMe. Check the latest studies of Differential white blood cell count abnormal.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 17, 2026

599,650 people reported to have side effects when taking Methotrexate.
Among them, 20 people (0.0%) have Differential white blood cell count abnormal.

Could Methotrexate cause Differential white blood cell count abnormal?

Among these 20 people:

How long have people been on Methotrexate when they have Differential white blood cell count abnormal? *

What is the gender of people who have Differential white blood cell count abnormal when taking Methotrexate? *

female: 78.95 %
male: 21.05 %

What is the age of people who have Differential white blood cell count abnormal when taking Methotrexate? *

What are other drugs people take besides Methotrexate? *

What are other side effects people have besides Differential white blood cell count abnormal? *

Haemoglobin Decreased: 10 people, 50.00%
Haematocrit Decreased: 9 people, 45.00%
Thrombocytopenia (decrease of platelets in blood): 7 people, 35.00%
Platelet Count Increased: 5 people, 25.00%
Aspartate Aminotransferase Increased: 5 people, 25.00%
Red Blood Cell Count Decreased: 5 people, 25.00%
White Blood Cell Count Increased: 5 people, 25.00%
Fever: 4 people, 20.00%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 4 people, 20.00%
Nausea (feeling of having an urge to vomit): 4 people, 20.00%

What are the existing conditions these people have? *

Wheezing (a high-pitched whistling sound made while you breath): 1 person, 5.00%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 1 person, 5.00%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 5.00%
Schizoaffective Disorder Bipolar Type (mental illness featuring schizophrenia and a mood disorder with mania): 1 person, 5.00%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 5.00%
Osteoporosis Post-Menopausal (weak bone with possibility to break after stopped menstrual cycles): 1 person, 5.00%
Osteoporosis (bones weak and more likely to break): 1 person, 5.00%
High Blood Pressure: 1 person, 5.00%
High Blood Cholesterol: 1 person, 5.00%
Dyspnea (difficult or laboured breathing): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Methotrexate and have Differential white blood cell count abnormal?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Methotrexate:

Methotrexate (604,313 reports)

Differential white blood cell count abnormal treatments and more:

Differential white blood cell count abnormal (2,986 reports)

How severe was Differential white blood cell count abnormal and when was it recovered:

Differential white blood cell count abnormal in Methotrexate

Expand to all the drugs that have ingredients of methotrexate sodium:

Differential white blood cell count abnormal and drugs with ingredients of methotrexate sodium (20 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Methotrexate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Differential white blood cell count abnormal:

Differential white blood cell count abnormal (89 drugs)

Browse all the conditions that are associated with Differential white blood cell count abnormal:

Differential white blood cell count abnormal (290 conditions)

Related publications that referenced our studies

Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .
Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on methotrexate sodium (the active ingredients of Methotrexate) and Methotrexate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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