Methotrexate and Ear buzzing - a phase IV clinical study of FDA data
Summary:
Ear buzzing is reported as a side effect among people who take Methotrexate (methotrexate sodium), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Humira, and have Psoriatic arthropathy.
The phase IV clinical study analyzes which people have Ear buzzing when taking Methotrexate. It is created by eHealthMe based on reports of 599,650 people who have side effects when taking Methotrexate from the FDA, and is updated regularly.
What is Methotrexate?
Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,307 Methotrexate users. Check the latest studies of Methotrexate.
What is Ear buzzing?
Ear buzzing is found to be associated with 2,385 drugs and 3,083 conditions by eHealthMe. Check the latest studies of Ear buzzing.
599,650 people reported to have side effects when taking Methotrexate.
Among them, 1,180 people (0.2%) have Ear buzzing.

Among these 1,180 people:
How long have people been on Methotrexate when they have Ear buzzing? *
What is the gender of people who have Ear buzzing when taking Methotrexate? *
What is the age of people who have Ear buzzing when taking Methotrexate? *
What are other drugs people take besides Methotrexate? *
What are other side effects people have besides Ear buzzing? *
What are the existing conditions these people have? *
* Approximation only. Some reports may have incomplete information.
Do you take Methotrexate and have Ear buzzing?
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Related studies:
Effectiveness of, long term effects of, and alternative drugs to Methotrexate:
- Methotrexate (604,307 reports)
Ear buzzing treatments and more:
- Ear buzzing (58,543 reports)
How severe was Ear buzzing and when was it recovered:
Expand to all the drugs that have ingredients of methotrexate sodium:
- Ear buzzing and drugs with ingredients of methotrexate sodium (1,182 reports)
Sub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Common Methotrexate side effects:
- Methotrexate side effect: Pain (54,804 reports)
Browse all side effects of Methotrexate:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon drugs associated with Ear buzzing:
- Aspirin side effect: Ear buzzing (2,601 reports)
- Cymbalta side effect: Ear buzzing (2,427 reports)
- Omeprazole side effect: Ear buzzing (1,980 reports)
- Prednisone side effect: Ear buzzing (1,929 reports)
- Gabapentin side effect: Ear buzzing (1,485 reports)
- Vitamin d side effect: Ear buzzing (1,427 reports)
- Simvastatin side effect: Ear buzzing (1,395 reports)
- Zide side effect: Ear buzzing (1,376 reports)
- Hydrochlorothiazide side effect: Ear buzzing (1,375 reports)
- Wellbutrin side effect: Ear buzzing (1,341 reports)
Browse all the drugs that are associated with Ear buzzing:
- Ear buzzing (2,385 drugs)
Common conditions associated with Ear buzzing:
- Depression aggravated: 3,635 reports
- Antidepressant therapy: 3,623 reports
- Hypertension aggravated: 2,663 reports
- Hbp: 2,652 reports
- Rheumatoid arthritis: 1,927 reports
- Anxiety: 1,913 reports
- Stress: 1,912 reports
- Pain exacerbated: 1,795 reports
- Alternative medicine - pain relief: 1,778 reports
- Blood cholesterol abnormal: 1,671 reports
Browse all the conditions that are associated with Ear buzzing:
- Ear buzzing (3,083 conditions)
Drugs similar to Methotrexate and Ear buzzing :
- Actemra side effect: Ear buzzing
- Arava side effect: Ear buzzing
- Celebrex side effect: Ear buzzing
- Enbrel side effect: Ear buzzing
- Folic acid side effect: Ear buzzing
- Humira side effect: Ear buzzing
- Hydroxychloroquine sulfate side effect: Ear buzzing
- Leflunomide side effect: Ear buzzing
- Orencia side effect: Ear buzzing
- Plaquenil side effect: Ear buzzing
- Prednisone side effect: Ear buzzing
- Remicade side effect: Ear buzzing
- Sulfasalazine side effect: Ear buzzing
Related publications that referenced our studies
- Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .
- Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .
How the study uses the data?
The study uses data from the FDA. It is based on methotrexate sodium (the active ingredients of Methotrexate) and Methotrexate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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