Methotrexate and Liver transplant - a phase IV clinical study of FDA data

Summary:

Liver transplant is reported as a side effect among people who take Methotrexate (methotrexate sodium), especially for people who are female, 20-29 old, have been taking the drug for 1 - 6 months also take Cyclophosphamide, and have Ulcerative colitis.

The phase IV clinical study analyzes which people have Liver transplant when taking Methotrexate. It is created by eHealthMe based on reports of 599,650 people who have side effects when taking Methotrexate from the FDA, and is updated regularly.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,314 Methotrexate users. Check the latest studies of Methotrexate.

What is Liver transplant?

Liver transplant is found to be associated with 331 drugs and 630 conditions by eHealthMe. Check the latest studies of Liver transplant.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

599,650 people reported to have side effects when taking Methotrexate.
Among them, 50 people (0.01%) have Liver transplant.

Could Methotrexate cause Liver transplant?

Among these 50 people:

How long have people been on Methotrexate when they have Liver transplant? *

What is the gender of people who have Liver transplant when taking Methotrexate? *

female: 65.31 %
male: 34.69 %

What is the age of people who have Liver transplant when taking Methotrexate? *

What are other drugs people take besides Methotrexate? *

What are other side effects people have besides Liver transplant? *

Hepatic Failure (liver failure): 20 people, 40.00%
Hepatic Necrosis (large portions of liver die off due to severe liver disease): 12 people, 24.00%
General Physical Health Deterioration (weak health status): 9 people, 18.00%
Jaundice - Yellow Skin (a yellowish pigmentation of the skin): 9 people, 18.00%
Encephalopathy (functioning of the brain is affected by some agent or condition): 8 people, 16.00%
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets): 7 people, 14.00%
Ascites (accumulation of fluid in the abdominal cavity): 7 people, 14.00%
Aspartate Aminotransferase Increased: 7 people, 14.00%
Coma Hepatic (accumulation in the bloodstream of toxic substances that are normally removed by the liver leads coma): 7 people, 14.00%
Hepatic Function Abnormal: 6 people, 12.00%

What are the existing conditions these people have? *

Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 5 people, 10.00%
Liver Disorder (liver diseases): 4 people, 8.00%
Tuberculin Test Positive: 3 people, 6.00%
High Blood Pressure: 2 people, 4.00%
Dermatomyositis (inflammation of the skin and underlying muscle tissue, typically occurring as an autoimmune condition or associated with internal cancer): 2 people, 4.00%
Latent Tuberculosis (hidden tuberculosis): 1 person, 2.00%
Juvenile Rheumatoid Arthritis (joint inflammation in children due to systemic disease): 1 person, 2.00%
Juvenile Arthritis (arthritis-related condition that develops in children or teenagers): 1 person, 2.00%
Inflammatory Bowel Disease: 1 person, 2.00%
Hyperlipidaemia (presence of excess lipids in the blood): 1 person, 2.00%

* Approximation only. Some reports may have incomplete information.

Do you take Methotrexate and have Liver transplant?

- Check whether Liver transplant is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Methotrexate:

Methotrexate (604,314 reports)

Liver transplant treatments and more:

Liver transplant (19,223 reports)

Browse all side effects of Methotrexate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Liver transplant:

Liver transplant (331 drugs)

Browse all the conditions that are associated with Liver transplant:

Liver transplant (630 conditions)

Related publications that referenced our studies

Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .
Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on methotrexate sodium (the active ingredients of Methotrexate) and Methotrexate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.