Methotrexate and Pilonidal cyst - a phase IV clinical study of FDA data

Summary:

Pilonidal cyst is reported as a side effect among people who take Methotrexate (methotrexate sodium), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Enbrel, and have Psoriasis.

The phase IV clinical study analyzes which people have Pilonidal cyst when taking Methotrexate. It is created by eHealthMe based on reports of 599,650 people who have side effects when taking Methotrexate from the FDA, and is updated regularly.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,313 Methotrexate users. Check the latest studies of Methotrexate.

What is Pilonidal cyst?

Pilonidal cyst is found to be associated with 107 drugs and 273 conditions by eHealthMe. Check the latest studies of Pilonidal cyst.

On Aug, 01, 2026

599,650 people reported to have side effects when taking Methotrexate.
Among them, 34 people (0.01%) have Pilonidal cyst.

Could Methotrexate cause Pilonidal cyst?

Among these 34 people:

How long have people been on Methotrexate when they have Pilonidal cyst? *

What is the gender of people who have Pilonidal cyst when taking Methotrexate? *

female: 44.12 %
male: 55.88 %

What is the age of people who have Pilonidal cyst when taking Methotrexate? *

What are other drugs people take besides Methotrexate? *

What are other side effects people have besides Pilonidal cyst? *

Joint Pain: 6 people, 17.65%
Pain In Extremity: 5 people, 14.71%
Cyst (a closed sac): 4 people, 11.76%
Fatigue (feeling of tiredness): 4 people, 11.76%
Pain: 3 people, 8.82%
High Blood Pressure: 3 people, 8.82%
Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 3 people, 8.82%
Stress And Anxiety: 3 people, 8.82%
Back Pain: 3 people, 8.82%
Cough: 3 people, 8.82%

What are the existing conditions these people have? *

Psoriasis (immune-mediated disease that affects the skin): 5 people, 14.71%
High Blood Pressure: 4 people, 11.76%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 8.82%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 3 people, 8.82%
Anaemia (lack of blood): 3 people, 8.82%
Pain: 2 people, 5.88%
Depression: 2 people, 5.88%
Lung Disorder (lung disease): 2 people, 5.88%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 2 people, 5.88%
Ankylosing Spondylitis (type of arthritis affecting the spine): 1 person, 2.94%

* Approximation only. Some reports may have incomplete information.

Do you take Methotrexate and have Pilonidal cyst?

- Check whether Pilonidal cyst is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Methotrexate:

Methotrexate (604,313 reports)

Browse all side effects of Methotrexate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Pilonidal cyst:

Pilonidal cyst (107 drugs)

Browse all the conditions that are associated with Pilonidal cyst:

Pilonidal cyst (273 conditions)

Related publications that referenced our studies

Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .
Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on methotrexate sodium (the active ingredients of Methotrexate) and Methotrexate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.