Will you have Trigeminal neuralgia with Methotrexate - from FDA reports

Summary

Trigeminal neuralgia is found among people who take Methotrexate, especially for people who are female, 50-59 old , have been taking the drug for 6 - 12 months, also take medication Enbrel, and have Psoriatic arthropathy. This study is created by eHealthMe based on reports of 304,233 people who have side effects when taking Methotrexate from FDA, and is updated regularly.



What's eHealthMe?

eHealthMe is a health data analysis company based in Mountain View, California. eHealthMe monitors and analyzes the outcomes of drugs and supplements that are currently on the market. The results are readily available to health care professionals and consumers.

eHealthMe has released original studies on market drugs and worked with leading universities and institutions such as IBM, London Health Science Centre, Mayo Clinic, Northwestern University and VA. eHealthMe studies have now been referenced in over 500 peer-reviewed medical publications.

How we gather our data?

Healthcare data is obtained from a number of sources including the Food and Drug Administration (FDA). This information is aggregated and used to produce personalized reports that patients can reference.

The information that eHealthMe collects includes:

  • Side effects (including severity and how people recover from them)
  • Associated conditions or symptoms
  • Drug effectiveness
  • Demographic data regarding drug use

How the study uses the data?

The study is based on methotrexate sodium (the active ingredients of Methotrexate) and Methotrexate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Synonyms of Trigeminal neuralgia are also considered in the study.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 307,853 users)

What is Trigeminal neuralgia?

Trigeminal neuralgia (a painful condition of the nerve responsible for most facial sensation) has been reported by people with multiple sclerosis, trigeminal neuralgia, osteoporosis, high blood pressure, pain (latest reports from 7,757 Trigeminal neuralgia patients).

How to use the study?

Patients can bring a copy of the report to their healthcare provider to ensure that all drug risks and benefits are fully discussed and understood. It is recommended that patients use the information presented as a part of a broader decision-making process.


On Mar, 20, 2019

304,233 people reported to have side effects when taking Methotrexate.
Among them, 38 people (0.01%) have Trigeminal neuralgia


Number of reports submitted per year:

Could Methotrexate cause Trigeminal neuralgia?

Time on Methotrexate when people have Trigeminal neuralgia *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 25 %
  • 6 - 12 months: 25 %
  • 1 - 2 years: 25 %
  • 2 - 5 years: 25 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Trigeminal neuralgia when taking Methotrexate *:

  • female: 94.59 %
  • male: 5.41 %

Age of people who have Trigeminal neuralgia when taking Methotrexate *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 7.41 %
  • 20-29: 0.0 %
  • 30-39: 7.41 %
  • 40-49: 14.81 %
  • 50-59: 40.74 %
  • 60+: 29.63 %

Top conditions involved for these people *:

  1. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 5 people, 13.16%
  2. Neuralgia (pain in one or more nerves): 3 people, 7.89%
  3. Depression: 3 people, 7.89%
  4. Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 7.89%
  5. High Blood Pressure: 3 people, 7.89%
  6. Psoriasis (immune-mediated disease that affects the skin): 2 people, 5.26%
  7. Pain: 2 people, 5.26%
  8. Migraine (headache): 1 person, 2.63%
  9. Acidosis (build-up of carbon dioxide in the blood): 1 person, 2.63%
  10. Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 1 person, 2.63%

Top co-used drugs for these people *:

  1. Humira: 12 people, 31.58%
  2. Enbrel: 12 people, 31.58%
  3. Folic Acid: 11 people, 28.95%
  4. Orencia: 5 people, 13.16%
  5. Lyrica: 4 people, 10.53%
  6. Remicade: 4 people, 10.53%
  7. Simvastatin: 3 people, 7.89%
  8. Celebrex: 3 people, 7.89%
  9. Trileptal: 3 people, 7.89%
  10. Diovan: 3 people, 7.89%

Top other side effects for these people *:

  1. Herpes Zoster: 5 people, 13.16%
  2. The Flu (the flu is caused by an influenza virus): 5 people, 13.16%
  3. Pain: 5 people, 13.16%
  4. Psoriasis (immune-mediated disease that affects the skin): 4 people, 10.53%
  5. Sinusitis (inflammation of sinus): 4 people, 10.53%
  6. Fibromyalgia (a long-term condition which causes pain all over the body): 4 people, 10.53%
  7. Fatigue (feeling of tiredness): 3 people, 7.89%
  8. Hair Loss: 3 people, 7.89%
  9. Joint Pain: 3 people, 7.89%
  10. Foot Deformity (functional disability of foot): 3 people, 7.89%

* Approximation only. Some reports may have incomplete information.


Do you have Trigeminal neuralgia while taking Methotrexate?

You are not alone:




Related publications that referenced our studies


Results from eHealthMe (non-FDA) reports of Trigeminal neuralgia with Methotrexate

Severity of Trigeminal neuralgia *:
  • least: 0.0 %
  • moderate: 50 %
  • severe: 50 %
  • most severe: 0.0 %
How people recovered from Trigeminal neuralgia *:
  • while on drug: 0.0 %
  • after off the drug: 0.0 %
  • not yet: 100 %
Effectiveness of Methotrexate when people have Trigeminal neuralgia *:
  • not at all: 0.0 %
  • somewhat: 75 %
  • moderate: 25 %
  • high: 0.0 %
  • very high: 0.0 %
Race of the people *:
  • African American, Non-Hispanic: 0.0 %
  • American Indian/Alaska Native: 0.0 %
  • Asian: 0.0 %
  • Hispanic: 0.0 %
  • Native Hawaiians/Pacific Islanders: 0.0 %
  • Two or more races: 0.0 %
  • White, Non-Hispanic: 100 %

* Approximation only.


Related studies

Drugs that are associated with Trigeminal neuralgia
Trigeminal neuralgia (816 drugs)
Could your condition cause Trigeminal neuralgia
Trigeminal neuralgia (529 conditions)
Methotrexate side effects

Browse side effects by gender and age

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+


Browse all side effects of Methotrexate
a b c d e f g h i j k l m n o p q r s t u v w x y z
Compare Methotrexate with similar drugs


What would happen?

Predict new side effects and undetected conditions when you take Methotrexate and have Trigeminal neuralgia



FDA reports used in this study


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