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Methylphenidate hydrochloride and Extrapyramidal disorder - a phase IV clinical study of FDA data

Summary:

Extrapyramidal disorder is reported as a side effect among people who take Methylphenidate hydrochloride (methylphenidate hydrochloride), especially for people who are male, 10-19 old, have been taking the drug for < 1 month also take Hydroxyzine, and have Aggression.

The phase IV clinical study analyzes which people have Extrapyramidal disorder when taking Methylphenidate hydrochloride. It is created by eHealthMe based on reports of 6,364 people who have side effects when taking Methylphenidate hydrochloride from the FDA, and is updated regularly.

What is Methylphenidate hydrochloride?

Methylphenidate hydrochloride has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 6,822 Methylphenidate hydrochloride users. Check the latest studies of Methylphenidate hydrochloride.

What is Extrapyramidal disorder?

Extrapyramidal disorder (involuntary muscle spasms in the face and neck) is found to be associated with 813 drugs and 960 conditions by eHealthMe. Check the latest studies of Extrapyramidal disorder.

On Jul, 14, 2026

6,364 people reported to have side effects when taking Methylphenidate hydrochloride.
Among them, 22 people (0.35%) have Extrapyramidal disorder.

Could Methylphenidate hydrochloride cause Extrapyramidal disorder?

Among these 22 people:

How long have people been on Methylphenidate hydrochloride when they have Extrapyramidal disorder? *

  • < 1 month: 50 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 50 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Extrapyramidal disorder when taking Methylphenidate hydrochloride? *

  • female: 5.56 %
  • male: 94.44 %

What is the age of people who have Extrapyramidal disorder when taking Methylphenidate hydrochloride? *

  • 0-1: 0.0 %
  • 2-9: 22.22 %
  • 10-19: 50.0 %
  • 20-29: 16.67 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 0.0 %
  • 60+: 11.11 %

What are other drugs people take besides Methylphenidate hydrochloride? *

  1. Bromocriptine Mesylate: 2 people, 9.09%
  2. Melatonin: 2 people, 9.09%
  3. Maprotiline Hydrochloride: 2 people, 9.09%
  4. Lithium Carbonate: 2 people, 9.09%
  5. Sertraline: 2 people, 9.09%
  6. Fluoxetine: 2 people, 9.09%
  7. Hydroxyzine: 2 people, 9.09%
  8. Valproic Acid: 1 person, 4.55%
  9. Hashish: 1 person, 4.55%
  10. Cannabis Sativa: 1 person, 4.55%

What are other side effects people have besides Extrapyramidal disorder? *

  1. Weight Increased: 8 people, 36.36%
  2. Drug Withdrawal Syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 6 people, 27.27%
  3. Drowsiness: 5 people, 22.73%
  4. Agitation (state of anxiety or nervous excitement): 4 people, 18.18%
  5. Tardive Dyskinesia (a disorder that involves involuntary movements): 3 people, 13.64%
  6. Gynecomastia (enlargement of the gland tissue of the male breast): 3 people, 13.64%
  7. Irritability: 3 people, 13.64%
  8. Headache (pain in head): 3 people, 13.64%
  9. Seizures (abnormal excessive or synchronous neuronal activity in the brain): 3 people, 13.64%
  10. Anal Fissure: 2 people, 9.09%

What are the existing conditions these people have? *

  1. Aggression: 7 people, 31.82%
  2. Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 3 people, 13.64%
  3. Bipolar Disorder (mood disorder): 3 people, 13.64%
  4. Tic (a sudden, repetitive, nonrhythmic motor movement or vocalization involving discrete muscle groups): 2 people, 9.09%
  5. Psychotic Disorder: 2 people, 9.09%
  6. Oppositional Defiant Disorder (a childhood disorder described by the diagnostic and statistical manual of mental disorders): 2 people, 9.09%
  7. Obsessive-Compulsive Disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;): 2 people, 9.09%
  8. Gilles De La Tourette Syndrome (a condition that causes people to make repeated, quick movements or sounds that they cannot control): 2 people, 9.09%
  9. Eating Disorder: 2 people, 9.09%
  10. Disturbance In Social Behavior: 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Methylphenidate hydrochloride and have Extrapyramidal disorder?

- Check whether Extrapyramidal disorder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Methylphenidate hydrochloride:

Extrapyramidal disorder treatments and more:

How severe was Extrapyramidal disorder and when was it recovered:

Expand to all the drugs that have ingredients of methylphenidate hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Methylphenidate hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Extrapyramidal disorder:

Browse all the conditions that are associated with Extrapyramidal disorder:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on methylphenidate hydrochloride (the active ingredients of Methylphenidate hydrochloride) and Methylphenidate hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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