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Methylphenidate hydrochloride and Raynaud's phenomenon - a phase IV clinical study of FDA data

Summary:

Raynaud's phenomenon is reported as a side effect among people who take Methylphenidate hydrochloride (methylphenidate hydrochloride), especially for people who are female, 30-39 old, have been taking the drug for 1 - 6 months also take Lexapro, and have Bipolar disorder.

The phase IV clinical study analyzes which people have Raynaud's phenomenon when taking Methylphenidate hydrochloride. It is created by eHealthMe based on reports of 6,364 people who have side effects when taking Methylphenidate hydrochloride from the FDA, and is updated regularly.

What is Methylphenidate hydrochloride?

Methylphenidate hydrochloride has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 6,822 Methylphenidate hydrochloride users. Check the latest studies of Methylphenidate hydrochloride.

What is Raynaud's phenomenon?

Raynaud's phenomenon (discoloration of the fingers, toes, and occasionally other areas) is found to be associated with 634 drugs and 995 conditions by eHealthMe. Check the latest studies of Raynaud's phenomenon.

On Jul, 12, 2026

6,364 people reported to have side effects when taking Methylphenidate hydrochloride.
Among them, 14 people (0.22%) have Raynaud's phenomenon.

Could Methylphenidate hydrochloride cause Raynaud's phenomenon?

Among these 14 people:

How long have people been on Methylphenidate hydrochloride when they have Raynaud's phenomenon? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 50 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 50 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Raynaud's phenomenon when taking Methylphenidate hydrochloride? *

  • female: 91.67 %
  • male: 8.33 %

What is the age of people who have Raynaud's phenomenon when taking Methylphenidate hydrochloride? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 16.67 %
  • 30-39: 50.0 %
  • 40-49: 0.0 %
  • 50-59: 16.67 %
  • 60+: 16.67 %

What are other drugs people take besides Methylphenidate hydrochloride? *

  1. Abilify: 4 people, 28.57%
  2. Lexapro: 4 people, 28.57%
  3. Xeljanz Xr: 2 people, 14.29%
  4. Amlodipine Besylate: 2 people, 14.29%
  5. Celecoxib: 2 people, 14.29%
  6. Amitriptyline Hydrochloride: 1 person, 7.14%
  7. Aimovig: 1 person, 7.14%
  8. Armodafinil: 1 person, 7.14%
  9. Aspirin: 1 person, 7.14%
  10. Baclofen: 1 person, 7.14%

What are other side effects people have besides Raynaud's phenomenon? *

  1. Skin Discoloration - Bluish (bluish colour of skin): 4 people, 28.57%
  2. Idiopathic Or Primary Livedo Reticularis (netlike pattern of reddish-blue skin discoloration, usually on the legs): 4 people, 28.57%
  3. Axonal Neuropathy (dysfunction of axon nerves): 4 people, 28.57%
  4. Hypoaesthesia (reduced sense of touch or sensation): 3 people, 21.43%
  5. Vision Blurred: 2 people, 14.29%
  6. Nasal Dryness (dry nose): 2 people, 14.29%
  7. Hair Loss: 2 people, 14.29%
  8. Headache (pain in head): 2 people, 14.29%
  9. Tremor (trembling or shaking movements in one or more parts of your body): 2 people, 14.29%
  10. Insomnia (sleeplessness): 2 people, 14.29%

What are the existing conditions these people have? *

  1. Psychomotor Hyperactivity (feelings of extreme restlessness): 4 people, 28.57%
  2. Bipolar Disorder (mood disorder): 4 people, 28.57%
  3. Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 2 people, 14.29%
  4. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 14.29%
  5. Rickets (softening of bones): 1 person, 7.14%
  6. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 7.14%
  7. Migraine (headache): 1 person, 7.14%
  8. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 7.14%
  9. Drowsiness: 1 person, 7.14%
  10. Cough: 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Methylphenidate hydrochloride and have Raynaud's phenomenon?

- Check whether Raynaud's phenomenon is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Methylphenidate hydrochloride:

Raynaud's phenomenon treatments and more:

How severe was Raynaud's phenomenon and when was it recovered:

Expand to all the drugs that have ingredients of methylphenidate hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Methylphenidate hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Raynaud's phenomenon:

Browse all the conditions that are associated with Raynaud's phenomenon:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on methylphenidate hydrochloride (the active ingredients of Methylphenidate hydrochloride) and Methylphenidate hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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