Percodan and Benadryl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Percodan (aspirin; oxycodone hydrochloride; oxycodone terephthalate) and Benadryl (diphenhydramine hydrochloride). Common drug interactions include abdominal pain among females and back pain among males.

The phase IV clinical study analyzes what interactions people have when they take Percodan and Benadryl. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Percodan?

Percodan has active ingredients of aspirin; oxycodone hydrochloride; oxycodone terephthalate. It is often used in pain. eHealthMe is studying from 12,885 Percodan users. Check the latest studies of Percodan.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,954 Benadryl users. Check the latest studies of Benadryl.

On Jul, 12, 2026

20 people who take Percodan and Benadryl together, and have interactions are studied.

Percodan and Benadryl drug interactions.

What are the common drug interactions of Percodan and Benadryl, by gender? *:

female:

Abdominal pain
Abdominal sepsis (abdominal infection)
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Asthenia (weakness)
Bone disorder
Breath odour
Cachexia (loss of weight)

male:

Back pain
Pulmonary oedema (fluid accumulation in the lungs)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Arthropathy
Asthenia (weakness)
Atrophic vulvovaginitis (inflammation of the vulva)
Bacterial infection
Balance disorder
Bone disorder
Bone swelling

What are the common drug interactions of Percodan and Benadryl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Headache (pain in head)
Hearing impaired
Intestinal obstruction
Joint injury
Malaise (a feeling of general discomfort or uneasiness)
Muscle spasms (muscle contraction)
Nausea (feeling of having an urge to vomit)
Osteonecrosis of jaw (death of bone of jaw)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Depression

50-59:

Abdominal pain
Abdominal sepsis (abdominal infection)
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Asthenia (weakness)
Bone disorder
Breath odour

60+:

Drug effect decreased
Drug hypersensitivity
Malaise (a feeling of general discomfort or uneasiness)
Renal failure acute (rapid kidney dysfunction)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Headache (pain in head)
Joint injury
Muscle spasms (muscle contraction)
Nausea (feeling of having an urge to vomit)
Osteonecrosis of jaw (death of bone of jaw)

What are the existing conditions these people have? *

Arthritis (form of joint disorder that involves inflammation of one or more joints): 3 people, 15.00%
Rectal Cancer Metastatic (cancer of rectum spreads to other): 1 person, 5.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

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