Morphine sulfate and Lactic acidosis - a phase IV clinical study of FDA data

Summary:

Lactic acidosis is reported as a side effect among people who take Morphine sulfate (morphine sulfate), especially for people who are female, 50-59 old, have been taking the drug for 1 - 6 months also take Acetaminophen, and have Type 2 diabetes.

The phase IV clinical study analyzes which people have Lactic acidosis when taking Morphine sulfate. It is created by eHealthMe based on reports of 86,091 people who have side effects when taking Morphine sulfate from the FDA, and is updated regularly.

What is Morphine sulfate?

Morphine sulfate has active ingredients of morphine sulfate. It is often used in pain. eHealthMe is studying from 87,261 Morphine sulfate users. Check the latest studies of Morphine sulfate.

What is Lactic acidosis?

Lactic acidosis (low ph in body tissues) is found to be associated with 994 drugs and 1,277 conditions by eHealthMe. Check the latest studies of Lactic acidosis.



On Jul, 20, 2026

86,091 people reported to have side effects when taking Morphine sulfate.
Among them, 58 people (0.07%) have Lactic acidosis.

Could Morphine sulfate cause Lactic acidosis?

Among these 58 people:

How long have people been on Morphine sulfate when they have Lactic acidosis? *

  • < 1 month: 28.57 %
  • 1 - 6 months: 71.43 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Lactic acidosis when taking Morphine sulfate? *

  • female: 62.96 %
  • male: 37.04 %

What is the age of people who have Lactic acidosis when taking Morphine sulfate? *

  • 0-1: 2.04 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 10.2 %
  • 30-39: 4.08 %
  • 40-49: 12.24 %
  • 50-59: 36.73 %
  • 60+: 34.69 %

What are other drugs people take besides Morphine sulfate? *

  1. Acetaminophen: 13 people, 22.41%
  2. Gabapentin: 11 people, 18.97%
  3. Glucophage: 8 people, 13.79%
  4. Metformin: 7 people, 12.07%
  5. Codeine: 7 people, 12.07%
  6. Lipitor: 5 people, 8.62%
  7. Neurontin: 5 people, 8.62%
  8. Viread: 5 people, 8.62%
  9. Kaletra: 5 people, 8.62%
  10. Prilosec: 5 people, 8.62%

What are other side effects people have besides Lactic acidosis? *

  1. Acute Kidney Failure: 16 people, 27.59%
  2. Hypotension (abnormally low blood pressure): 15 people, 25.86%
  3. Hepatic Failure (liver failure): 12 people, 20.69%
  4. Hypoglycemia (low blood sugar): 11 people, 18.97%
  5. Overdose: 11 people, 18.97%
  6. Pneumonia: 11 people, 18.97%
  7. Mental Status Changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation): 10 people, 17.24%
  8. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 10 people, 17.24%
  9. Hypokalemia (low potassium): 10 people, 17.24%
  10. Consciousness - Decreased: 10 people, 17.24%

What are the existing conditions these people have? *

  1. Type 2 Diabetes: 7 people, 12.07%
  2. High Blood Pressure: 6 people, 10.34%
  3. Headache (pain in head): 5 people, 8.62%
  4. Overdose: 5 people, 8.62%
  5. Hiv Infection: 5 people, 8.62%
  6. Diabetes: 3 people, 5.17%
  7. Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve): 3 people, 5.17%
  8. Procedural Pain: 3 people, 5.17%
  9. Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 5.17%
  10. Insomnia (sleeplessness): 2 people, 3.45%

* Approximation only. Some reports may have incomplete information.

Do you take Morphine sulfate and have Lactic acidosis?

- Check whether Lactic acidosis is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Morphine sulfate:

Lactic acidosis treatments and more:

How severe was Lactic acidosis and when was it recovered:

Expand to all the drugs that have ingredients of morphine sulfate:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Morphine sulfate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Lactic acidosis:

Browse all the conditions that are associated with Lactic acidosis:

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on morphine sulfate (the active ingredients of Morphine sulfate) and Morphine sulfate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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