Paxil cr and Zolpidem drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Paxil cr (paroxetine hydrochloride) and Zolpidem (zolpidem tartrate). Common drug interactions include disorientation among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Paxil cr and Zolpidem. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Paxil cr?

Paxil cr has active ingredients of paroxetine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 8,322 Paxil cr users. Check the latest studies of Paxil cr.

What is Zolpidem?

Zolpidem has active ingredients of zolpidem tartrate. It is often used in insomnia. eHealthMe is studying from 92,695 Zolpidem users. Check the latest studies of Zolpidem.



On Jul, 20, 2026

30 people who take Paxil cr and Zolpidem together, and have interactions are studied.

Paxil cr and Zolpidem drug interactions.

What are the common drug interactions of Paxil Cr and Zolpidem, by gender? *:

female:

  1. Disorientation (disability in which the senses of time, direction, and recognition of people and places)
  2. Dizziness
  3. Dyspnoea (difficult or laboured respiration)
  4. Dysstasia (difficulty in standing)
  5. Ear pain
  6. Faeces discoloured
  7. Fracture
  8. Full blood count increased
  9. Fungal skin infection
  10. Gait disturbance

male:

  1. Pneumonia
  2. Neonatal asphyxia (a condition in which an extreme decrease in the concentration of oxygen in the body accompanied by an increase in the concentration of carbon dioxide in neonate)
  3. Renal impairment (severely reduced kidney function)
  4. Staphylococcal infection (an infection with staphylococcus bacteria)
  5. Blood immunoglobulin g decreased
  6. Diarrhoea
  7. Haemorrhoids (a swollen vein or group of veins in the region of the anus)
  8. Hypertension (high blood pressure)
  9. Abscess neck (neck abscesses)
  10. Blood calcium decreased

What are the common drug interactions of Paxil Cr and Zolpidem, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Blood immunoglobulin g decreased
  2. Diarrhoea
  3. Haemorrhoids (a swollen vein or group of veins in the region of the anus)
  4. Hypertension (high blood pressure)
  5. Pneumonia

30-39:

  1. Abscess neck (neck abscesses)
  2. Injection site erythema (redness at injection site)
  3. Injection site induration
  4. Injection site infection
  5. Injection site inflammation
  6. Injection site pain
  7. Injection site swelling
  8. Injection site warmth
  9. Renal impairment (severely reduced kidney function)
  10. Weight increased

40-49:

  1. Acne (skin problems that cause pimples)
  2. Diarrhoea
  3. Drug ineffective
  4. Headache (pain in head)
  5. Hypokalaemia (low potassium)
  6. Iron deficiency anaemia
  7. Stomatitis (inflammation of mucous membrane of mouth)

50-59:

  1. Altered state of consciousness (altered state of mind)
  2. Cough
  3. Drug eruption (adverse drug reaction of the skin)
  4. Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
  5. Inappropriate antidiuretic hormone secretion
  6. Infectious pleural effusion (infectious fluid in the lung)
  7. Lung infection
  8. Pneumonia
  9. Pyrexia (fever)
  10. Staphylococcal infection (an infection with staphylococcus bacteria)

60+:

  1. Fall
  2. Inappropriate antidiuretic hormone secretion
  3. Paralysis
  4. Acute respiratory failure
  5. Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
  6. Dyspnoea exertional (breathlessness or shortness of breath)
  7. Fatigue (feeling of tiredness)
  8. Hypoxia (low oxygen in tissues)
  9. Non-cardiogenic pulmonary oedema (protein and fluid accumulation in the alveoli without pulmonary capillary pressure)
  10. Somnolence (a state of near-sleep, a strong desire for sleep)

What are the existing conditions these people have? *

  1. Depression: 10 people, 33.33%
  2. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 20.00%
  3. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 16.67%
  4. Multiple Myeloma (cancer of the plasma cells): 4 people, 13.33%
  5. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 13.33%
  6. Fibromyalgia (a long-term condition which causes pain all over the body): 4 people, 13.33%
  7. Hiv Infection: 3 people, 10.00%
  8. Osteoporosis (bones weak and more likely to break): 2 people, 6.67%
  9. Lung Cancer - Non-Small Cell (lung cancer): 2 people, 6.67%
  10. Lung Adenocarcinoma (a form of non-small cell lung cancer): 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Paxil cr and Zolpidem:

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Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Paxil cr:

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Browse all side effects of Zolpidem:

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Browse all interactions between Paxil cr and drugs from A to Z:

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Browse all interactions between Zolpidem and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on paroxetine hydrochloride and zolpidem tartrate (the active ingredients of Paxil cr and Zolpidem, respectively), and Paxil cr and Zolpidem (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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