Morphine and Ear barotrauma - a phase IV clinical study of FDA data

Summary:

Ear barotrauma is reported as a side effect among people who take Morphine (morphine sulfate), especially for people who are male, 40-49 old, also take Aredia, and have Hypercalcaemia of malignancy.

The phase IV clinical study analyzes which people have Ear barotrauma when taking Morphine. It is created by eHealthMe based on reports of 180,723 people who have side effects when taking Morphine from the FDA, and is updated regularly.

What is Morphine?

Morphine has active ingredients of morphine sulfate. It is often used in pain. eHealthMe is studying from 182,914 Morphine users. Check the latest studies of Morphine.

What is Ear barotrauma?

Ear barotrauma (discomfort and possible damage in the ear due to pressure differences between the inside and outside of the eardrum) is found to be associated with 300 drugs and 625 conditions by eHealthMe. Check the latest studies of Ear barotrauma.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 10, 2026

180,723 people reported to have side effects when taking Morphine.
Among them, 13 people (0.01%) have Ear barotrauma.

Among these 13 people:

What is the gender of people who have Ear barotrauma when taking Morphine? *

female: 46.15 %
male: 53.85 %

What is the age of people who have Ear barotrauma when taking Morphine? *

What are other drugs people take besides Morphine? *

What are other side effects people have besides Ear barotrauma? *

Tenderness (pain or discomfort when an affected area is touched): 9 people, 69.23%
Stress And Anxiety: 9 people, 69.23%
Chest Pain: 9 people, 69.23%
Dyspnea (difficult or laboured breathing): 8 people, 61.54%
Fall: 8 people, 61.54%
Joint Pain: 8 people, 61.54%
Hypoaesthesia (reduced sense of touch or sensation): 8 people, 61.54%
Fatigue (feeling of tiredness): 8 people, 61.54%
Osteosclerosis (an elevation in bone density): 7 people, 53.85%
Pneumonia: 7 people, 53.85%

What are the existing conditions these people have? *

Hypercalcaemia Of Malignancy (elevated calcium (ca+) level in the blood with cancer): 4 people, 30.77%
Metastases To Bone (cancer spreads to bone): 3 people, 23.08%
Stress And Anxiety: 1 person, 7.69%
Multiple Myeloma (cancer of the plasma cells): 1 person, 7.69%
Discomfort: 1 person, 7.69%
Generalized Anxiety Disorder (excessive, uncontrollable, unexplained and often irrational worry): 1 person, 7.69%
Hypercalcaemia (elevated calcium (ca+) level in the blood): 1 person, 7.69%
Hypochondria (health phobia or health anxiety): 1 person, 7.69%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 7.69%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Morphine and have Ear barotrauma?

- Check whether Ear barotrauma is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Morphine:

Morphine (182,914 reports)

Ear barotrauma treatments and more:

Ear barotrauma (1,478 reports)

Browse all side effects of Morphine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Ear barotrauma:

Ear barotrauma (300 drugs)

Browse all the conditions that are associated with Ear barotrauma:

Ear barotrauma (625 conditions)

Related publications that referenced our studies

Rasmy A, Rahal M, Kisana M, Ahmad S, Salah A, "Morphine induced thrombocytopenia: A case report", Journal of Case Reports and Images in Oncology, 2015 Dec .
Rasmy A, Rahal M, Kisana M, Ahmad S, Salah A, "Morphine induced thrombocytopenia: A case report", Journal of Case Reports and Images in Oncology, 2015 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on morphine sulfate (the active ingredients of Morphine) and Morphine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.