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Vitamin c and Application site swelling - a phase IV clinical study of FDA data

Summary:

Application site swelling is reported as a side effect among people who take Vitamin c (l-ascorbic acid), especially for people who are male, 60+ old, also take Vitamin D, and have Fungal infection.

The phase IV clinical study analyzes which people have Application site swelling when taking Vitamin c. It is created by eHealthMe based on reports of 89,802 people who have side effects when taking Vitamin c from the FDA, and is updated regularly.

What is Vitamin c?

Vitamin c has active ingredients of l-ascorbic acid. It is often used in immune response. eHealthMe is studying from 92,472 Vitamin c users. Check the latest studies of Vitamin c.

What is Application site swelling?

Application site swelling is found to be associated with 215 drugs and 479 conditions by eHealthMe. Check the latest studies of Application site swelling.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

89,802 people reported to have side effects when taking Vitamin c.
Among them, 16 people (0.02%) have Application site swelling.

Could Vitamin c cause Application site swelling?

Among these 16 people:

What is the gender of people who have Application site swelling when taking Vitamin c? *

  • female: 46.67 %
  • male: 53.33 %

What is the age of people who have Application site swelling when taking Vitamin c? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 7.69 %
  • 30-39: 7.69 %
  • 40-49: 7.69 %
  • 50-59: 15.38 %
  • 60+: 61.54 %

What are other drugs people take besides Vitamin c? *

  1. Vitamin D: 7 people, 43.75%
  2. Fish Oil: 4 people, 25.00%
  3. Synthroid: 3 people, 18.75%
  4. Vitamin B12: 3 people, 18.75%
  5. Magnesium: 2 people, 12.50%
  6. Lamictal: 2 people, 12.50%
  7. Valchlor: 2 people, 12.50%
  8. Monistat 1 Combination Pack: 2 people, 12.50%
  9. Vitamin D3: 2 people, 12.50%
  10. Calcium: 2 people, 12.50%

What are other side effects people have besides Application site swelling? *

  1. Application Site Erythema (redness of the skin at application site): 7 people, 43.75%
  2. Application Site Pain: 4 people, 25.00%
  3. Application Site Pruritus (application site severe itching of the skin): 4 people, 25.00%
  4. Application Site Vesicles (small bubble within a cell at application site): 3 people, 18.75%
  5. Application Site Discharge: 2 people, 12.50%
  6. Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure): 2 people, 12.50%
  7. Application Site Scab (hard coating on the skin formed at application site): 2 people, 12.50%
  8. Application Site Irritation: 2 people, 12.50%
  9. Application Site Rash: 2 people, 12.50%
  10. Peripheral Swelling: 2 people, 12.50%

What are the existing conditions these people have? *

  1. Pain: 2 people, 12.50%
  2. Fungal Infection: 2 people, 12.50%
  3. Wound: 1 person, 6.25%
  4. High Blood Cholesterol: 1 person, 6.25%
  5. Malaise (a feeling of general discomfort or uneasiness): 1 person, 6.25%
  6. Intervertebral Disc Degeneration (spinal disc degeneration): 1 person, 6.25%
  7. Indigestion: 1 person, 6.25%
  8. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 6.25%
  9. High Blood Pressure: 1 person, 6.25%
  10. Headache (pain in head): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Vitamin c and have Application site swelling?

- Check whether Application site swelling is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Vitamin c:

Application site swelling treatments and more:

How severe was Application site swelling and when was it recovered:

Expand to all the drugs that have ingredients of l-ascorbic acid:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Vitamin c:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Application site swelling:

Browse all the conditions that are associated with Application site swelling:

How the study uses the data?

The study uses data from the FDA. It is based on l-ascorbic acid (the active ingredients of Vitamin c) and Vitamin c (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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