Morphine and Gallbladder operation - a phase IV clinical study of FDA data

Summary:

Gallbladder operation is reported as a side effect among people who take Morphine (morphine sulfate), especially for people who are female, 60+ old, also take Methotrexate, and have Crohn's disease.

The phase IV clinical study analyzes which people have Gallbladder operation when taking Morphine. It is created by eHealthMe based on reports of 180,723 people who have side effects when taking Morphine from the FDA, and is updated regularly.

What is Morphine?

Morphine has active ingredients of morphine sulfate. It is often used in pain. eHealthMe is studying from 182,913 Morphine users. Check the latest studies of Morphine.

What is Gallbladder operation?

Gallbladder operation is found to be associated with 341 drugs and 778 conditions by eHealthMe. Check the latest studies of Gallbladder operation.

On Jul, 18, 2026

180,723 people reported to have side effects when taking Morphine.
Among them, 25 people (0.01%) have Gallbladder operation.

Could Morphine cause Gallbladder operation?

Among these 25 people:

What is the gender of people who have Gallbladder operation when taking Morphine? *

female: 52.38 %
male: 47.62 %

What is the age of people who have Gallbladder operation when taking Morphine? *

What are other drugs people take besides Morphine? *

What are other side effects people have besides Gallbladder operation? *

Diarrhea: 9 people, 36.00%
Malaise (a feeling of general discomfort or uneasiness): 8 people, 32.00%
Nausea (feeling of having an urge to vomit): 8 people, 32.00%
Headache (pain in head): 7 people, 28.00%
Abdominal Pain Upper: 7 people, 28.00%
Drug Level Below Therapeutic: 6 people, 24.00%
Abdominal Distension: 6 people, 24.00%
Haemorrhoids (a swollen vein or group of veins in the region of the anus): 6 people, 24.00%
Oropharyngeal Pain: 6 people, 24.00%
Abscess (pus): 6 people, 24.00%

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 6 people, 24.00%
Colorectal Cancer Metastatic (cancer of colon and rectal spreads to other parts): 3 people, 12.00%
Ankylosing Spondylitis (type of arthritis affecting the spine): 3 people, 12.00%
Abdominal Discomfort: 3 people, 12.00%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 2 people, 8.00%
Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 2 people, 8.00%
Muscle Spasms (muscle contraction): 2 people, 8.00%
Iron Overload: 2 people, 8.00%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 2 people, 8.00%
Anaemia (lack of blood): 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

Do you take Morphine and have Gallbladder operation?

- Check whether Gallbladder operation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Morphine:

Morphine (182,913 reports)

Browse all side effects of Morphine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Gallbladder operation:

Gallbladder operation (341 drugs)

Browse all the conditions that are associated with Gallbladder operation:

Gallbladder operation (778 conditions)

Related publications that referenced our studies

Rasmy A, Rahal M, Kisana M, Ahmad S, Salah A, "Morphine induced thrombocytopenia: A case report", Journal of Case Reports and Images in Oncology, 2015 Dec .
Rasmy A, Rahal M, Kisana M, Ahmad S, Salah A, "Morphine induced thrombocytopenia: A case report", Journal of Case Reports and Images in Oncology, 2015 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on morphine sulfate (the active ingredients of Morphine) and Morphine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.