Morphine and Kounis syndrome - a phase IV clinical study of FDA data

Summary:

Kounis syndrome is reported as a side effect among people who take Morphine (morphine sulfate), especially for people who are male, 30-39 old, also take Cefazolin, and have Upper respiratory tract infection.

The phase IV clinical study analyzes which people have Kounis syndrome when taking Morphine. It is created by eHealthMe based on reports of 180,723 people who have side effects when taking Morphine from the FDA, and is updated regularly.

What is Morphine?

Morphine has active ingredients of morphine sulfate. It is often used in pain. eHealthMe is studying from 182,914 Morphine users. Check the latest studies of Morphine.

What is Kounis syndrome?

Kounis syndrome (the concurrence of heart pain with conditions associated with mast cell activation leads to heart muscle damage) is found to be associated with 122 drugs and 203 conditions by eHealthMe. Check the latest studies of Kounis syndrome.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

180,723 people reported to have side effects when taking Morphine.
Among them, 19 people (0.01%) have Kounis syndrome.

Among these 19 people:

What is the gender of people who have Kounis syndrome when taking Morphine? *

female: 27.78 %
male: 72.22 %

What is the age of people who have Kounis syndrome when taking Morphine? *

What are other drugs people take besides Morphine? *

Cefazolin: 9 people, 47.37%
Methimazole: 6 people, 31.58%
Amoxicillin And Clavulanate Potassium: 5 people, 26.32%
Propofol: 3 people, 15.79%
Fentanyl: 3 people, 15.79%
Dexmedetomidine Hydrochloride: 3 people, 15.79%
Clopidogrel: 2 people, 10.53%
Ondansetron: 1 person, 5.26%
Diclofenac: 1 person, 5.26%
Adrenaclick: 1 person, 5.26%

What are other side effects people have besides Kounis syndrome? *

Hypersensitivity: 4 people, 21.05%
Stable Angina (a constant chest pain): 3 people, 15.79%
Acute Coronary Syndrome (acute chest pain and other symptoms that happen because the heart does not get blood): 2 people, 10.53%
Heart Attack: 2 people, 10.53%
Chest Pain: 2 people, 10.53%
Rash Erythematous (redness of the skin): 2 people, 10.53%
Confusional State: 1 person, 5.26%
Disease Recurrence: 1 person, 5.26%
Electrocardiogram St Segment Elevation: 1 person, 5.26%
Fainting (loss of consciousness and postural tone): 1 person, 5.26%

What are the existing conditions these people have? *

Upper Respiratory Tract Infection: 8 people, 42.11%
Renal Colic (renal pain): 2 people, 10.53%
Stress Cardiomyopathy (stress-induced chronic disease of the heart muscle): 1 person, 5.26%
Nausea (feeling of having an urge to vomit): 1 person, 5.26%
Joint Pain: 1 person, 5.26%
Hypotension (abnormally low blood pressure): 1 person, 5.26%
Chest Pain: 1 person, 5.26%
Angioedema (rapid swelling of the dermis): 1 person, 5.26%
Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Morphine and have Kounis syndrome?

- Check whether Kounis syndrome is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Morphine:

Morphine (182,914 reports)

Kounis syndrome treatments and more:

Kounis syndrome (2,190 reports)

Browse all side effects of Morphine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Kounis syndrome:

Kounis syndrome (122 drugs)

Browse all the conditions that are associated with Kounis syndrome:

Kounis syndrome (203 conditions)

Related publications that referenced our studies

Rasmy A, Rahal M, Kisana M, Ahmad S, Salah A, "Morphine induced thrombocytopenia: A case report", Journal of Case Reports and Images in Oncology, 2015 Dec .
Rasmy A, Rahal M, Kisana M, Ahmad S, Salah A, "Morphine induced thrombocytopenia: A case report", Journal of Case Reports and Images in Oncology, 2015 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on morphine sulfate (the active ingredients of Morphine) and Morphine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.