Morphine and Pneumatosis intestinalis - a phase IV clinical study of FDA data

Summary:

Pneumatosis intestinalis is reported as a side effect among people who take Morphine (morphine sulfate), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Lasix, and have Colorectal cancer metastatic.

The phase IV clinical study analyzes which people have Pneumatosis intestinalis when taking Morphine. It is created by eHealthMe based on reports of 180,723 people who have side effects when taking Morphine from the FDA, and is updated regularly.

What is Morphine?

Morphine has active ingredients of morphine sulfate. It is often used in pain. eHealthMe is studying from 182,914 Morphine users. Check the latest studies of Morphine.

What is Pneumatosis intestinalis?

Pneumatosis intestinalis (air or gas in an intestine) is found to be associated with 255 drugs and 489 conditions by eHealthMe. Check the latest studies of Pneumatosis intestinalis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

180,723 people reported to have side effects when taking Morphine.
Among them, 35 people (0.02%) have Pneumatosis intestinalis.

Could Morphine cause Pneumatosis intestinalis?

Among these 35 people:

How long have people been on Morphine when they have Pneumatosis intestinalis? *

What is the gender of people who have Pneumatosis intestinalis when taking Morphine? *

female: 68.57 %
male: 31.43 %

What is the age of people who have Pneumatosis intestinalis when taking Morphine? *

What are other drugs people take besides Morphine? *

Lasix: 10 people, 28.57%
Ondansetron: 9 people, 25.71%
Acetaminophen: 7 people, 20.00%
Hydroxyzine Hydrochloride: 7 people, 20.00%
Lorazepam: 7 people, 20.00%
Metoclopramide: 7 people, 20.00%
Vancomycin: 6 people, 17.14%
Heparin: 6 people, 17.14%
Sucralfate: 6 people, 17.14%
Melatonin: 6 people, 17.14%

What are other side effects people have besides Pneumatosis intestinalis? *

Fever: 9 people, 25.71%
Anaemia (lack of blood): 8 people, 22.86%
Ascites (accumulation of fluid in the abdominal cavity): 8 people, 22.86%
Abdominal Pain: 7 people, 20.00%
Disease Progression: 7 people, 20.00%
Abdominal Distension: 6 people, 17.14%
Diarrhea: 6 people, 17.14%
Oxygen Saturation Decreased: 6 people, 17.14%
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood): 5 people, 14.29%
Aspartate Aminotransferase Increased: 5 people, 14.29%

What are the existing conditions these people have? *

Portopulmonary Hypertension (coexistence of portal and pulmonary hypertension): 5 people, 14.29%
Colorectal Cancer Metastatic (cancer of colon and rectal spreads to other parts): 5 people, 14.29%
Neuroblastoma (a cancer that forms in your nerve tissue): 4 people, 11.43%
Face Oedema (swelling of face): 4 people, 11.43%
Endometrial Cancer: 3 people, 8.57%
Bone Pain: 3 people, 8.57%
Oxygen Saturation Decreased: 2 people, 5.71%
Multiple Myeloma (cancer of the plasma cells): 2 people, 5.71%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 5.71%
Irritability: 2 people, 5.71%

* Approximation only. Some reports may have incomplete information.

Do you take Morphine and have Pneumatosis intestinalis?

- Check whether Pneumatosis intestinalis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Morphine:

Morphine (182,914 reports)

Browse all side effects of Morphine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Pneumatosis intestinalis:

Pneumatosis intestinalis (255 drugs)

Browse all the conditions that are associated with Pneumatosis intestinalis:

Pneumatosis intestinalis (489 conditions)

Related publications that referenced our studies

Rasmy A, Rahal M, Kisana M, Ahmad S, Salah A, "Morphine induced thrombocytopenia: A case report", Journal of Case Reports and Images in Oncology, 2015 Dec .
O'rafferty C, McElligott F, Storey L, O'marcaigh A, Smith O, "Pneumatosis intestinalis and imatinib mesylate", Annals of hematology, 2014 Oct .
Rasmy A, Rahal M, Kisana M, Ahmad S, Salah A, "Morphine induced thrombocytopenia: A case report", Journal of Case Reports and Images in Oncology, 2015 Dec .
O'rafferty C, McElligott F, Storey L, O'marcaigh A, Smith O, "Pneumatosis intestinalis and imatinib mesylate", Annals of hematology, 2014 Oct .

How the study uses the data?

The study uses data from the FDA. It is based on morphine sulfate (the active ingredients of Morphine) and Morphine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.