Namenda and Irritability - a phase IV clinical study of FDA data

Summary:

Irritability is reported as a side effect among people who take Namenda (memantine hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Aricept, and have Dementia alzheimer's type.

The phase IV clinical study analyzes which people have Irritability when taking Namenda. It is created by eHealthMe based on reports of 13,521 people who have side effects when taking Namenda from the FDA, and is updated regularly.

What is Namenda?

Namenda has active ingredients of memantine hydrochloride. It is often used in dementia. eHealthMe is studying from 14,283 Namenda users. Check the latest studies of Namenda.

What is Irritability?

Irritability is found to be associated with 1,696 drugs and 2,462 conditions by eHealthMe. Check the latest studies of Irritability.

On Aug, 10, 2026

13,521 people reported to have side effects when taking Namenda.
Among them, 83 people (0.61%) have Irritability.

Among these 83 people:

How long have people been on Namenda when they have Irritability? *

What is the gender of people who have Irritability when taking Namenda? *

female: 50.63 %
male: 49.37 %

What is the age of people who have Irritability when taking Namenda? *

What are other drugs people take besides Namenda? *

What are other side effects people have besides Irritability? *

Depression: 17 people, 20.48%
Drowsiness: 17 people, 20.48%
Fatigue (feeling of tiredness): 17 people, 20.48%
Aggression: 15 people, 18.07%
Agitation (state of anxiety or nervous excitement): 14 people, 16.87%
Pain: 13 people, 15.66%
Confusional State: 12 people, 14.46%
Weakness: 12 people, 14.46%
Pain In Extremity: 11 people, 13.25%
Nausea (feeling of having an urge to vomit): 10 people, 12.05%

What are the existing conditions these people have? *

Dementia Alzheimer's Type (loss of mental ability with alzheimer's symptom): 15 people, 18.07%
Depression: 13 people, 15.66%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 9 people, 10.84%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 10.84%
Parkinson's Disease: 9 people, 10.84%
Hallucinations (sensations that appear real but are created by your mind): 8 people, 9.64%
Neuropathy Peripheral (surface nerve damage): 7 people, 8.43%
Depressed Level Of Consciousness: 7 people, 8.43%
Weakness: 7 people, 8.43%
Drowsiness: 7 people, 8.43%

* Approximation only. Some reports may have incomplete information.

Do you take Namenda and have Irritability?

- Check whether Irritability is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Namenda:

Namenda (14,283 reports)

Irritability treatments and more:

Irritability (71,614 reports)

Browse all side effects of Namenda:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Irritability:

Irritability (1,696 drugs)

Browse all the conditions that are associated with Irritability:

Irritability (2,462 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on memantine hydrochloride (the active ingredients of Namenda) and Namenda (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.