Naproxen and Essential hypertension - a phase IV clinical study of FDA data

Summary:

Essential hypertension is reported as a side effect among people who take Naproxen (naproxen), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Clonazepam, and have Constipation.

The phase IV clinical study analyzes which people have Essential hypertension when taking Naproxen. It is created by eHealthMe based on reports of 68,942 people who have side effects when taking Naproxen from the FDA, and is updated regularly.

What is Naproxen?

Naproxen has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 72,033 Naproxen users. Check the latest studies of Naproxen.

What is Essential hypertension?

Essential hypertension (primary hypertension) is found to be associated with 661 drugs and 652 conditions by eHealthMe. Check the latest studies of Essential hypertension.



On Jul, 31, 2026

68,942 people reported to have side effects when taking Naproxen.
Among them, 36 people (0.05%) have Essential hypertension.

Could Naproxen cause Essential hypertension?

Among these 36 people:

How long have people been on Naproxen when they have Essential hypertension? *

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Essential hypertension when taking Naproxen? *

  • female: 60 %
  • male: 40 %

What is the age of people who have Essential hypertension when taking Naproxen? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 21.88 %
  • 50-59: 46.88 %
  • 60+: 31.25 %

What are other drugs people take besides Naproxen? *

  1. Fluconazole: 11 people, 30.56%
  2. Vicodin: 11 people, 30.56%
  3. Clonazepam: 11 people, 30.56%
  4. Lorazepam: 10 people, 27.78%
  5. Levaquin: 10 people, 27.78%
  6. Flexeril: 10 people, 27.78%
  7. Percocet: 10 people, 27.78%
  8. Prednisone: 10 people, 27.78%
  9. Zantac: 9 people, 25.00%
  10. Fentanyl: 9 people, 25.00%

What are other side effects people have besides Essential hypertension? *

  1. Fatigue (feeling of tiredness): 16 people, 44.44%
  2. Depression: 15 people, 41.67%
  3. Dizziness: 14 people, 38.89%
  4. Dyspnea (difficult or laboured breathing): 13 people, 36.11%
  5. Constipation: 12 people, 33.33%
  6. Urinary Tract Infection: 12 people, 33.33%
  7. Nausea (feeling of having an urge to vomit): 12 people, 33.33%
  8. Muscle Aches (muscle pain): 11 people, 30.56%
  9. Oedema Peripheral (superficial swelling): 11 people, 30.56%
  10. Fall: 11 people, 30.56%

What are the existing conditions these people have? *

  1. High Blood Pressure: 7 people, 19.44%
  2. Bone Pain: 7 people, 19.44%
  3. Breast Cancer: 7 people, 19.44%
  4. Metastases To Bone (cancer spreads to bone): 7 people, 19.44%
  5. Constipation: 7 people, 19.44%
  6. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 11.11%
  7. Depression: 4 people, 11.11%
  8. High Blood Cholesterol: 3 people, 8.33%
  9. Bipolar Disorder (mood disorder): 3 people, 8.33%
  10. Blood Pressure Abnormal: 2 people, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Naproxen and have Essential hypertension?

- Check whether Essential hypertension is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously



Related studies:

Effectiveness of, long term effects of, and alternative drugs to Naproxen:

Essential hypertension treatments and more:

How severe was Essential hypertension and when was it recovered:

Expand to all the drugs that have ingredients of naproxen:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Naproxen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Essential hypertension:

Browse all the conditions that are associated with Essential hypertension:


How the study uses the data?

The study uses data from the FDA. It is based on naproxen (the active ingredients of Naproxen) and Naproxen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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