Naproxen and Joint lock - a phase IV clinical study of FDA data

Summary:

Joint lock is reported as a side effect among people who take Naproxen (naproxen), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Methotrexate, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Joint lock when taking Naproxen. It is created by eHealthMe based on reports of 68,942 people who have side effects when taking Naproxen from the FDA, and is updated regularly.

What is Naproxen?

Naproxen has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 72,032 Naproxen users. Check the latest studies of Naproxen.

What is Joint lock?

Joint lock is found to be associated with 302 drugs and 490 conditions by eHealthMe. Check the latest studies of Joint lock.

On Jul, 06, 2026

68,942 people reported to have side effects when taking Naproxen.
Among them, 43 people (0.06%) have Joint lock.

Among these 43 people:

How long have people been on Naproxen when they have Joint lock? *

What is the gender of people who have Joint lock when taking Naproxen? *

female: 66.67 %
male: 33.33 %

What is the age of people who have Joint lock when taking Naproxen? *

What are other drugs people take besides Naproxen? *

What are other side effects people have besides Joint lock? *

Joint Swelling: 24 people, 55.81%
Joint Pain: 21 people, 48.84%
Pain In Extremity: 19 people, 44.19%
Drug Ineffective: 17 people, 39.53%
Gait Disturbance: 17 people, 39.53%
Peripheral Swelling: 17 people, 39.53%
Infusion Site Urticaria (rash of round, red welts on the skin at infusion site): 14 people, 32.56%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 14 people, 32.56%
Dysstasia (difficulty in standing): 14 people, 32.56%
General Physical Health Deterioration (weak health status): 14 people, 32.56%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 10 people, 23.26%
Joint Injury: 5 people, 11.63%
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve): 2 people, 4.65%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 4.65%
Diabetes: 2 people, 4.65%
Ankylosing Spondylitis (type of arthritis affecting the spine): 2 people, 4.65%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 2.33%
Migraine (headache): 1 person, 2.33%
Interstitial Lung Disease: 1 person, 2.33%
High Blood Pressure: 1 person, 2.33%

* Approximation only. Some reports may have incomplete information.

Do you take Naproxen and have Joint lock?

- Check whether Joint lock is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Naproxen:

Naproxen (72,032 reports)

Joint lock treatments and more:

Joint lock (3,416 reports)

Browse all side effects of Naproxen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Joint lock:

Joint lock (302 drugs)

Browse all the conditions that are associated with Joint lock:

Joint lock (490 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on naproxen (the active ingredients of Naproxen) and Naproxen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.