Naproxen and Large intestine perforation - a phase IV clinical study of FDA data

Summary:

Large intestine perforation is reported as a side effect among people who take Naproxen (naproxen), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Nexium, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Large intestine perforation when taking Naproxen. It is created by eHealthMe based on reports of 68,942 people who have side effects when taking Naproxen from the FDA, and is updated regularly.

What is Naproxen?

Naproxen has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 72,034 Naproxen users. Check the latest studies of Naproxen.

What is Large intestine perforation?

Large intestine perforation (hole in large intestine) is found to be associated with 634 drugs and 794 conditions by eHealthMe. Check the latest studies of Large intestine perforation.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

68,942 people reported to have side effects when taking Naproxen.
Among them, 33 people (0.05%) have Large intestine perforation.

Could Naproxen cause Large intestine perforation?

Among these 33 people:

How long have people been on Naproxen when they have Large intestine perforation? *

What is the gender of people who have Large intestine perforation when taking Naproxen? *

female: 36.67 %
male: 63.33 %

What is the age of people who have Large intestine perforation when taking Naproxen? *

What are other drugs people take besides Naproxen? *

What are other side effects people have besides Large intestine perforation? *

Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs): 5 people, 15.15%
Haematoma (collection of blood outside the blood vessels): 5 people, 15.15%
Abscess (pus): 5 people, 15.15%
Post Procedural Complication: 4 people, 12.12%
Infection: 4 people, 12.12%
Intestinal Fistula: 4 people, 12.12%
Diarrhea: 4 people, 12.12%
Night Sweats (sweating in night): 4 people, 12.12%
Diverticular Fistula: 4 people, 12.12%
Gastric Disorder (disease of stomach): 4 people, 12.12%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 7 people, 21.21%
Nausea (feeling of having an urge to vomit): 4 people, 12.12%
Gastric Ulcer (stomach ulcer): 3 people, 9.09%
Asthma: 3 people, 9.09%
Cancer Pain: 3 people, 9.09%
Constipation: 3 people, 9.09%
Enterocolitis (inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon): 3 people, 9.09%
Herpes Zoster: 2 people, 6.06%
Cardiac Sarcoidosis (an immune disorder): 2 people, 6.06%
Abdominal Pain: 2 people, 6.06%

* Approximation only. Some reports may have incomplete information.

Do you take Naproxen and have Large intestine perforation?

- Check whether Large intestine perforation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Naproxen:

Naproxen (72,034 reports)

Browse all side effects of Naproxen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Large intestine perforation:

Large intestine perforation (634 drugs)

Browse all the conditions that are associated with Large intestine perforation:

Large intestine perforation (794 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on naproxen (the active ingredients of Naproxen) and Naproxen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.