Naproxen and Muscle rigidity - a phase IV clinical study of FDA data

Summary:

Muscle rigidity is reported as a side effect among people who take Naproxen (naproxen), especially for people who are female, 60+ old, have been taking the drug for 1 - 2 years also take Acetaminophen, and have Parkinson's disease.

The phase IV clinical study analyzes which people have Muscle rigidity when taking Naproxen. It is created by eHealthMe based on reports of 68,942 people who have side effects when taking Naproxen from the FDA, and is updated regularly.

What is Naproxen?

Naproxen has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 72,032 Naproxen users. Check the latest studies of Naproxen.

What is Muscle rigidity?

Muscle rigidity (muscle stiffness) is found to be associated with 785 drugs and 1,035 conditions by eHealthMe. Check the latest studies of Muscle rigidity.

On Jul, 15, 2026

68,942 people reported to have side effects when taking Naproxen.
Among them, 98 people (0.14%) have Muscle rigidity.

Among these 98 people:

How long have people been on Naproxen when they have Muscle rigidity? *

What is the gender of people who have Muscle rigidity when taking Naproxen? *

female: 68.89 %
male: 31.11 %

What is the age of people who have Muscle rigidity when taking Naproxen? *

What are other drugs people take besides Naproxen? *

What are other side effects people have besides Muscle rigidity? *

Tremor (trembling or shaking movements in one or more parts of your body): 33 people, 33.67%
Stress And Anxiety: 29 people, 29.59%
Hallucinations (sensations that appear real but are created by your mind): 27 people, 27.55%
Fever: 27 people, 27.55%
Agitation (state of anxiety or nervous excitement): 23 people, 23.47%
Mobility Decreased (ability to move is reduced): 22 people, 22.45%
Mydriasis (a dilation of the pupil): 21 people, 21.43%
Joint Pain: 19 people, 19.39%
Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles): 19 people, 19.39%
Pain In Extremity: 19 people, 19.39%

What are the existing conditions these people have? *

Parkinson's Disease: 16 people, 16.33%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 10 people, 10.20%
Depression: 10 people, 10.20%
Ankylosing Spondylitis (type of arthritis affecting the spine): 9 people, 9.18%
Psoriasis (immune-mediated disease that affects the skin): 4 people, 4.08%
Suicide Attempt: 4 people, 4.08%
Stress And Anxiety: 4 people, 4.08%
Bowel Movement Irregularity: 4 people, 4.08%
Progressive Multiple Sclerosis (chronic autoimmune disease of the central nervous system in which gradual destruction of myelin occurs in patches throughout the brain or spinal cord): 4 people, 4.08%
Agitation (state of anxiety or nervous excitement): 3 people, 3.06%

* Approximation only. Some reports may have incomplete information.

Do you take Naproxen and have Muscle rigidity?

- Check whether Muscle rigidity is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Naproxen:

Naproxen (72,032 reports)

Muscle rigidity treatments and more:

Muscle rigidity (16,888 reports)

Browse all side effects of Naproxen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Muscle rigidity:

Muscle rigidity (785 drugs)

Browse all the conditions that are associated with Muscle rigidity:

Muscle rigidity (1,035 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on naproxen (the active ingredients of Naproxen) and Naproxen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.