Naproxen and Venous insufficiency - a phase IV clinical study of FDA data

Summary:

Venous insufficiency is reported as a side effect among people who take Naproxen (naproxen), especially for people who are female, 60+ old, also take Furosemide, and have Osteoporosis.

The phase IV clinical study analyzes which people have Venous insufficiency when taking Naproxen. It is created by eHealthMe based on reports of 68,942 people who have side effects when taking Naproxen from the FDA, and is updated regularly.

What is Naproxen?

Naproxen has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 72,033 Naproxen users. Check the latest studies of Naproxen.

What is Venous insufficiency?

Venous insufficiency (poor circulation of blood caused by damaged or enlarged veins) is found to be associated with 385 drugs and 558 conditions by eHealthMe. Check the latest studies of Venous insufficiency.

On Aug, 12, 2026

68,942 people reported to have side effects when taking Naproxen.
Among them, 30 people (0.04%) have Venous insufficiency.

Could Naproxen cause Venous insufficiency?

Among these 30 people:

What is the gender of people who have Venous insufficiency when taking Naproxen? *

female: 96.55 %
male: 3.45 %

What is the age of people who have Venous insufficiency when taking Naproxen? *

What are other drugs people take besides Naproxen? *

What are other side effects people have besides Venous insufficiency? *

Oedema Peripheral (superficial swelling): 22 people, 73.33%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 17 people, 56.67%
Joint Pain: 14 people, 46.67%
Pain In Extremity: 13 people, 43.33%
Fatigue (feeling of tiredness): 13 people, 43.33%
Urinary Tract Infection: 13 people, 43.33%
Gastritis (inflammation of stomach): 12 people, 40.00%
Dyspnea (difficult or laboured breathing): 12 people, 40.00%
Weakness: 11 people, 36.67%
Itching: 11 people, 36.67%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 11 people, 36.67%
Birth Control: 7 people, 23.33%
High Blood Cholesterol: 5 people, 16.67%
Hyperlipidaemia (presence of excess lipids in the blood): 5 people, 16.67%
Sleep Disorder: 5 people, 16.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 16.67%
Gravitational Oedema (abnormally large fluid volume in the circulatory system makes obese): 5 people, 16.67%
Cardiac Disorder: 3 people, 10.00%
Chest Pain: 3 people, 10.00%
Constipation: 3 people, 10.00%

* Approximation only. Some reports may have incomplete information.

Do you take Naproxen and have Venous insufficiency?

- Check whether Venous insufficiency is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Naproxen:

Naproxen (72,033 reports)

Browse all side effects of Naproxen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Venous insufficiency:

Venous insufficiency (385 drugs)

Browse all the conditions that are associated with Venous insufficiency:

Venous insufficiency (558 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on naproxen (the active ingredients of Naproxen) and Naproxen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.