Nexium and Synovial rupture - a phase IV clinical study of FDA data

Summary:

Synovial rupture is reported as a side effect among people who take Nexium (esomeprazole magnesium), especially for people who are female, 50-59 old, also take Lipitor, and have Allergic rhinitis.

The phase IV clinical study analyzes which people have Synovial rupture when taking Nexium. It is created by eHealthMe based on reports of 240,870 people who have side effects when taking Nexium from the FDA, and is updated regularly.

What is Nexium?

Nexium has active ingredients of esomeprazole magnesium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 245,678 Nexium users. Check the latest studies of Nexium.

What is Synovial rupture?

Synovial rupture (tear of synovial membrane of joint) is found to be associated with 118 drugs and 157 conditions by eHealthMe. Check the latest studies of Synovial rupture.

On Aug, 08, 2026

240,870 people reported to have side effects when taking Nexium.
Among them, 17 people (0.01%) have Synovial rupture.

Among these 17 people:

What is the gender of people who have Synovial rupture when taking Nexium? *

female: 88.24 %
male: 11.76 %

What is the age of people who have Synovial rupture when taking Nexium? *

What are other drugs people take besides Nexium? *

Lipitor: 14 people, 82.35%
Ramipril: 13 people, 76.47%
Simvastatin: 11 people, 64.71%
Losartan Potassium And Hydrochlorothiazide: 10 people, 58.82%
Zocor: 2 people, 11.76%
Effexor: 2 people, 11.76%
Xanax: 2 people, 11.76%
Humira: 2 people, 11.76%
Prednisone: 1 person, 5.88%
Detrol: 1 person, 5.88%

What are other side effects people have besides Synovial rupture? *

White Blood Cell Count Increased: 14 people, 82.35%
Nausea And Vomiting: 14 people, 82.35%
Abdominal Pain: 14 people, 82.35%
Cardiac Disorder: 14 people, 82.35%
Chest Pain: 14 people, 82.35%
Cholangitis (infection of the bile duct): 14 people, 82.35%
Diaphragmatic Disorder: 14 people, 82.35%
Headache (pain in head): 14 people, 82.35%
Hepatic Enzyme Increased: 14 people, 82.35%
High Blood Cholesterol: 14 people, 82.35%

What are the existing conditions these people have? *

Indigestion: 12 people, 70.59%
Allergic Rhinitis: 12 people, 70.59%
Stress And Anxiety: 2 people, 11.76%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 11.76%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 11.76%
Hyperchlorhydria (gastric acid levels are higher in stomach): 2 people, 11.76%
Sleep Disorder: 1 person, 5.88%
Raynaud's Phenomenon (discoloration of the fingers, toes, and occasionally other areas): 1 person, 5.88%
Peripheral Sensory Neuropathy (damage to one or more of your peripheral nerves): 1 person, 5.88%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Nexium and have Synovial rupture?

- Check whether Synovial rupture is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Nexium:

Nexium (245,678 reports)

Browse all side effects of Nexium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Synovial rupture:

Synovial rupture (118 drugs)

Browse all the conditions that are associated with Synovial rupture:

Synovial rupture (157 conditions)

Related publications that referenced our studies

Dr. Anthony Wong, "Esomeprazole and gynaecomastia in obese adults", WHO pharmaceuticals newsletter: 2019, No. 2, 2019 Jan .
Dr. Anthony Wong, "Esomeprazole and gynaecomastia in obese adults", WHO pharmaceuticals newsletter: 2019, No. 2, 2019 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on esomeprazole magnesium (the active ingredients of Nexium) and Nexium (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.