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Nitrous oxide and Anaphylaxis - a phase IV clinical study of FDA data

Summary:

Anaphylaxis is reported as a side effect among people who take Nitrous oxide (nitrous oxide), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Midazolam, and have General anaesthesia.

The phase IV clinical study analyzes which people have Anaphylaxis when taking Nitrous oxide. It is created by eHealthMe based on reports of 1,772 people who have side effects when taking Nitrous oxide from the FDA, and is updated regularly.

What is Nitrous oxide?

Nitrous oxide has active ingredients of nitrous oxide. eHealthMe is studying from 1,780 Nitrous oxide users. Check the latest studies of Nitrous oxide.

What is Anaphylaxis?

Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death) is found to be associated with 1,935 drugs and 2,856 conditions by eHealthMe. Check the latest studies of Anaphylaxis.

On Jul, 28, 2026

1,772 people reported to have side effects when taking Nitrous oxide.
Among them, 46 people (2.6%) have Anaphylaxis.

Could Nitrous oxide cause Anaphylaxis?

Among these 46 people:

How long have people been on Nitrous oxide when they have Anaphylaxis? *

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Anaphylaxis when taking Nitrous oxide? *

  • female: 58.54 %
  • male: 41.46 %

What is the age of people who have Anaphylaxis when taking Nitrous oxide? *

  • 0-1: 2.44 %
  • 2-9: 19.51 %
  • 10-19: 14.63 %
  • 20-29: 2.44 %
  • 30-39: 4.88 %
  • 40-49: 31.71 %
  • 50-59: 7.32 %
  • 60+: 17.07 %

What are other drugs people take besides Nitrous oxide? *

  1. Midazolam: 22 people, 47.83%
  2. Fentanyl: 11 people, 23.91%
  3. Propofol: 11 people, 23.91%
  4. Sevoflurane: 10 people, 21.74%
  5. Lidocaine: 8 people, 17.39%
  6. Vancomycin: 5 people, 10.87%
  7. Epinephrine: 5 people, 10.87%
  8. Vancomycin Hydrochloride: 3 people, 6.52%
  9. Bridion: 3 people, 6.52%
  10. Xolair: 2 people, 4.35%

What are other side effects people have besides Anaphylaxis? *

  1. Hypotension (abnormally low blood pressure): 10 people, 21.74%
  2. Bradycardia (abnormally slow heart action): 9 people, 19.57%
  3. Cardiac Arrest: 8 people, 17.39%
  4. Metabolic Acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body): 6 people, 13.04%
  5. Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 6 people, 13.04%
  6. Impaired Healing: 5 people, 10.87%
  7. Rash Maculo-Papular (red area on the skin that is covered with small confluent bumps): 5 people, 10.87%
  8. Lip Swelling: 5 people, 10.87%
  9. Angioedema (rapid swelling of the dermis): 5 people, 10.87%
  10. Urticaria (rash of round, red welts on the skin that itch intensely): 5 people, 10.87%

What are the existing conditions these people have? *

  1. General Anaesthesia: 17 people, 36.96%
  2. High Blood Pressure: 10 people, 21.74%
  3. Anaesthesia: 9 people, 19.57%
  4. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 9 people, 19.57%
  5. Stress And Anxiety: 8 people, 17.39%
  6. Sedation: 5 people, 10.87%
  7. Neuromuscular Blockade Reversal: 3 people, 6.52%
  8. Hypersensitivity: 2 people, 4.35%
  9. Asthma: 2 people, 4.35%
  10. Idiopathic Urticaria (allergic reactions, presence of hives with unknown cause): 2 people, 4.35%

* Approximation only. Some reports may have incomplete information.

Do you take Nitrous oxide and have Anaphylaxis?

- Check whether Anaphylaxis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Nitrous oxide:

Anaphylaxis treatments and more:

How severe was Anaphylaxis and when was it recovered:

Expand to all the drugs that have ingredients of nitrous oxide:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Nitrous oxide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Anaphylaxis:

Browse all the conditions that are associated with Anaphylaxis:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on nitrous oxide (the active ingredients of Nitrous oxide) and Nitrous oxide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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