Norco and Venous insufficiency - a phase IV clinical study of FDA data

Summary:

Venous insufficiency is reported as a side effect among people who take Norco (acetaminophen; hydrocodone bitartrate), especially for people who are male, 60+ old, also take Aspirin, and have Hypothyroidism.

The phase IV clinical study analyzes which people have Venous insufficiency when taking Norco. It is created by eHealthMe based on reports of 71,619 people who have side effects when taking Norco from the FDA, and is updated regularly.

What is Norco?

Norco has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 74,063 Norco users. Check the latest studies of Norco.

What is Venous insufficiency?

Venous insufficiency (poor circulation of blood caused by damaged or enlarged veins) is found to be associated with 385 drugs and 558 conditions by eHealthMe. Check the latest studies of Venous insufficiency.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

71,619 people reported to have side effects when taking Norco.
Among them, 16 people (0.02%) have Venous insufficiency.

Among these 16 people:

What is the gender of people who have Venous insufficiency when taking Norco? *

female: 25 %
male: 75 %

What is the age of people who have Venous insufficiency when taking Norco? *

What are other drugs people take besides Norco? *

What are other side effects people have besides Venous insufficiency? *

Chest Pain: 10 people, 62.50%
Cardiac Failure Congestive: 9 people, 56.25%
Pain In Extremity: 9 people, 56.25%
Dyspnea (difficult or laboured breathing): 8 people, 50.00%
Oedema Peripheral (superficial swelling): 8 people, 50.00%
Nausea (feeling of having an urge to vomit): 8 people, 50.00%
Oedema (fluid collection in tissue): 7 people, 43.75%
Rashes (redness): 7 people, 43.75%
Fatigue (feeling of tiredness): 6 people, 37.50%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 6 people, 37.50%

What are the existing conditions these people have? *

Type 2 Diabetes: 5 people, 31.25%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 31.25%
High Blood Pressure: 2 people, 12.50%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 12.50%
Reflux Oesophagitis (an oesophageal mucosal injury that occurs of gastric contents into the oesophagus): 2 people, 12.50%
High Blood Cholesterol: 1 person, 6.25%
Bladder Cancer: 1 person, 6.25%
Blood Triglycerides Decreased: 1 person, 6.25%
Cardiac Failure Congestive: 1 person, 6.25%
Diarrhea: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Norco and have Venous insufficiency?

- Check whether Venous insufficiency is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Norco:

Norco (74,063 reports)

Venous insufficiency treatments and more:

Venous insufficiency (1,909 reports)

How severe was Venous insufficiency and when was it recovered:

Venous insufficiency in Norco

Expand to all the drugs that have ingredients of acetaminophen; hydrocodone bitartrate:

Venous insufficiency and drugs with ingredients of acetaminophen; hydrocodone bitartrate (109 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Norco:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Venous insufficiency:

Venous insufficiency (385 drugs)

Browse all the conditions that are associated with Venous insufficiency:

Venous insufficiency (558 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; hydrocodone bitartrate (the active ingredients of Norco) and Norco (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.