Norflex and Constipation - a phase IV clinical study of FDA data

Summary:

Constipation is reported as a side effect among people who take Norflex (orphenadrine citrate), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Toradol, and have Pain.

The phase IV clinical study analyzes which people have Constipation when taking Norflex. It is created by eHealthMe based on reports of 1,749 people who have side effects when taking Norflex from the FDA, and is updated regularly.

What is Norflex?

Norflex has active ingredients of orphenadrine citrate. It is often used in muscle spasms. eHealthMe is studying from 1,951 Norflex users. Check the latest studies of Norflex.

What is Constipation?

Constipation is found to be associated with 3,004 drugs and 4,619 conditions by eHealthMe. Check the latest studies of Constipation.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Jul, 04, 2026

1,749 people reported to have side effects when taking Norflex.
Among them, 60 people (3.43%) have Constipation.

Among these 60 people:

How long have people been on Norflex when they have Constipation? *

What is the gender of people who have Constipation when taking Norflex? *

female: 68.97 %
male: 31.03 %

What is the age of people who have Constipation when taking Norflex? *

What are other drugs people take besides Norflex? *

What are other side effects people have besides Constipation? *

Chest Pain: 27 people, 45.00%
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 26 people, 43.33%
Dyspnea (difficult or laboured breathing): 26 people, 43.33%
Hypoaesthesia (reduced sense of touch or sensation): 26 people, 43.33%
Nausea (feeling of having an urge to vomit): 25 people, 41.67%
Joint Pain: 22 people, 36.67%
Dizziness: 22 people, 36.67%
Pain: 21 people, 35.00%
Weakness: 18 people, 30.00%
Stress And Anxiety: 17 people, 28.33%

What are the existing conditions these people have? *

Pain: 11 people, 18.33%
Neck Pain: 9 people, 15.00%
High Blood Pressure: 6 people, 10.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 6.67%
Drowsiness: 4 people, 6.67%
Back Injury: 3 people, 5.00%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 5.00%
Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 2 people, 3.33%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 3.33%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 2 people, 3.33%

* Approximation only. Some reports may have incomplete information.

Do you take Norflex and have Constipation?

- Check whether Constipation is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Norflex:

Norflex (1,951 reports)

Constipation treatments and more:

Constipation (337,881 reports)

Browse all side effects of Norflex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Constipation:

Constipation (3,004 drugs)

Browse all the conditions that are associated with Constipation:

Constipation (4,619 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on orphenadrine citrate (the active ingredients of Norflex) and Norflex (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.