Norflex and Pruritus aggravated - a phase IV clinical study of FDA data

Summary:

Pruritus aggravated is reported as a side effect among people who take Norflex (orphenadrine citrate), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Humira, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Pruritus aggravated when taking Norflex. It is created by eHealthMe based on reports of 1,749 people who have side effects when taking Norflex from the FDA, and is updated regularly.

What is Norflex?

Norflex has active ingredients of orphenadrine citrate. It is often used in muscle spasms. eHealthMe is studying from 1,951 Norflex users. Check the latest studies of Norflex.

What is Pruritus aggravated?

Pruritus aggravated (serious severe itching of the skin) is found to be associated with 2,483 drugs and 1,071 conditions by eHealthMe. Check the latest studies of Pruritus aggravated.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

1,749 people reported to have side effects when taking Norflex.
Among them, 52 people (2.97%) have Pruritus aggravated.

Could Norflex cause Pruritus aggravated?

Among these 52 people:

How long have people been on Norflex when they have Pruritus aggravated? *

What is the gender of people who have Pruritus aggravated when taking Norflex? *

female: 84.31 %
male: 15.69 %

What is the age of people who have Pruritus aggravated when taking Norflex? *

What are other drugs people take besides Norflex? *

What are other side effects people have besides Pruritus aggravated? *

Rashes (redness): 21 people, 40.38%
Headache (pain in head): 20 people, 38.46%
Joint Pain: 18 people, 34.62%
Pain: 17 people, 32.69%
Herpes Zoster: 16 people, 30.77%
Fatigue (feeling of tiredness): 16 people, 30.77%
Nausea (feeling of having an urge to vomit): 15 people, 28.85%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 14 people, 26.92%
Fibromyalgia (a long-term condition which causes pain all over the body): 14 people, 26.92%
Swelling: 13 people, 25.00%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 17 people, 32.69%
Pain: 7 people, 13.46%
Joint Pain: 6 people, 11.54%
High Blood Pressure: 3 people, 5.77%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 3 people, 5.77%
Essential Hypertension (primary hypertension): 3 people, 5.77%
Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 5.77%
Migraine (headache): 3 people, 5.77%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 3.85%
Depression: 2 people, 3.85%

* Approximation only. Some reports may have incomplete information.

Do you take Norflex and have Pruritus aggravated?

- Check whether Pruritus aggravated is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Norflex:

Norflex (1,951 reports)

Browse all side effects of Norflex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Pruritus aggravated:

Pruritus aggravated (2,484 drugs)

Browse all the conditions that are associated with Pruritus aggravated:

Pruritus aggravated (1,071 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on orphenadrine citrate (the active ingredients of Norflex) and Norflex (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.