Norvasc and Diverticular perforation - a phase IV clinical study of FDA data

Summary:

Diverticular perforation is reported as a side effect among people who take Norvasc (amlodipine besylate), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Lasix, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Diverticular perforation when taking Norvasc. It is created by eHealthMe based on reports of 133,505 people who have side effects when taking Norvasc from the FDA, and is updated regularly.

What is Norvasc?

Norvasc has active ingredients of amlodipine besylate. It is often used in high blood pressure. eHealthMe is studying from 136,738 Norvasc users. Check the latest studies of Norvasc.

What is Diverticular perforation?

Diverticular perforation (serious gastrointestinal condition in which the intestine's walls are perforated) is found to be associated with 367 drugs and 413 conditions by eHealthMe. Check the latest studies of Diverticular perforation.

On Jul, 28, 2026

133,505 people reported to have side effects when taking Norvasc.
Among them, 36 people (0.03%) have Diverticular perforation.

Could Norvasc cause Diverticular perforation?

Among these 36 people:

How long have people been on Norvasc when they have Diverticular perforation? *

What is the gender of people who have Diverticular perforation when taking Norvasc? *

female: 54.84 %
male: 45.16 %

What is the age of people who have Diverticular perforation when taking Norvasc? *

What are other drugs people take besides Norvasc? *

What are other side effects people have besides Diverticular perforation? *

Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs): 12 people, 33.33%
Post Procedural Complication: 5 people, 13.89%
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall): 4 people, 11.11%
Large Intestine Perforation (hole in large intestine): 4 people, 11.11%
Dyspnea (difficult or laboured breathing): 3 people, 8.33%
Mallory-Weiss Syndrome (gastro-oesophageal laceration syndrome refers to bleeding from tears): 3 people, 8.33%
Pneumonia: 3 people, 8.33%
Pulmonary Embolism (blockage of the main artery of the lung): 3 people, 8.33%
Hiatal Hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm): 3 people, 8.33%
Gastroenteritis Viral (inflammation of stomach and intestine caused by virus infection): 3 people, 8.33%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 6 people, 16.67%
Pain: 4 people, 11.11%
Candidiasis (candidiasis or thrush is a fungal infection): 3 people, 8.33%
Cough: 3 people, 8.33%
Hyperlipidaemia (presence of excess lipids in the blood): 3 people, 8.33%
Osteoporosis (bones weak and more likely to break): 3 people, 8.33%
Breast Cancer: 3 people, 8.33%
Multiple Myeloma (cancer of the plasma cells): 2 people, 5.56%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 5.56%
Hyperkalemia (damage to or disease of the kidney): 2 people, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Norvasc and have Diverticular perforation?

- Check whether Diverticular perforation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Norvasc:

Norvasc (136,738 reports)

Browse all side effects of Norvasc:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Diverticular perforation:

Diverticular perforation (367 drugs)

Browse all the conditions that are associated with Diverticular perforation:

Diverticular perforation (413 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on amlodipine besylate (the active ingredients of Norvasc) and Norvasc (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.