Novalgin and Joint stiffness - a phase IV clinical study of FDA data

Summary:

Joint stiffness is reported as a side effect among people who take Novalgin (metamizole), especially for people who are male, 40-49 old, have been taking the drug for 1 - 6 months also take Pantoprazole, and have Psoriatic arthropathy.

The phase IV clinical study analyzes which people have Joint stiffness when taking Novalgin. It is created by eHealthMe based on reports of 10,087 people who have side effects when taking Novalgin from the FDA, and is updated regularly.

What is Novalgin?

Novalgin has active ingredients of metamizole. It is often used in pain. eHealthMe is studying from 10,177 Novalgin users. Check the latest studies of Novalgin.

What is Joint stiffness?

Joint stiffness is found to be associated with 1,301 drugs and 1,340 conditions by eHealthMe. Check the latest studies of Joint stiffness.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

10,087 people reported to have side effects when taking Novalgin.
Among them, 11 people (0.11%) have Joint stiffness.

Among these 11 people:

How long have people been on Novalgin when they have Joint stiffness? *

What is the gender of people who have Joint stiffness when taking Novalgin? *

female: 27.27 %
male: 72.73 %

What is the age of people who have Joint stiffness when taking Novalgin? *

What are other drugs people take besides Novalgin? *

What are other side effects people have besides Joint stiffness? *

Movement Disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness): 6 people, 54.55%
Joint Pain: 6 people, 54.55%
Pain In Extremity: 6 people, 54.55%
Rhinorrhea (watery mucus discharge from the nose): 5 people, 45.45%
Eye Irritation: 5 people, 45.45%
Nasopharyngitis (inflammation of the nasopharynx): 5 people, 45.45%
Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 5 people, 45.45%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 5 people, 45.45%
Spinal Pain (pain in spine): 5 people, 45.45%
Exfoliative Rash (scaly red generalized skin rash): 5 people, 45.45%

What are the existing conditions these people have? *

Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 6 people, 54.55%
Rickets (softening of bones): 5 people, 45.45%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 45.45%
Osteoporosis (bones weak and more likely to break): 5 people, 45.45%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 5 people, 45.45%
High Blood Pressure: 5 people, 45.45%
Immune Tolerance Induction: 3 people, 27.27%
Myosclerosis (hardening of muscle tissue): 1 person, 9.09%
Joint Pain: 1 person, 9.09%
Hiatal Hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Novalgin and have Joint stiffness?

- Check whether Joint stiffness is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Novalgin:

Novalgin (10,177 reports)

Joint stiffness treatments and more:

Joint stiffness (33,165 reports)

Browse all side effects of Novalgin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Joint stiffness:

Joint stiffness (1,301 drugs)

Browse all the conditions that are associated with Joint stiffness:

Joint stiffness (1,340 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on metamizole (the active ingredients of Novalgin) and Novalgin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.