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Nucynta and Systemic lupus erythematosus - a phase IV clinical study of FDA data

Summary:

Systemic lupus erythematosus is reported as a side effect among people who take Nucynta (tapentadol hydrochloride), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Humira, and have Crohn's disease.

The phase IV clinical study analyzes which people have Systemic lupus erythematosus when taking Nucynta. It is created by eHealthMe based on reports of 31,342 people who have side effects when taking Nucynta from the FDA, and is updated regularly.

What is Nucynta?

Nucynta has active ingredients of tapentadol hydrochloride. It is often used in pain. eHealthMe is studying from 31,818 Nucynta users. Check the latest studies of Nucynta.

What is Systemic lupus erythematosus?

Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue) is found to be associated with 1,086 drugs and 1,645 conditions by eHealthMe. Check the latest studies of Systemic lupus erythematosus.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Jul, 13, 2026

31,342 people reported to have side effects when taking Nucynta.
Among them, 13 people (0.04%) have Systemic lupus erythematosus.

Could Nucynta cause Systemic lupus erythematosus?

Among these 13 people:

How long have people been on Nucynta when they have Systemic lupus erythematosus? *

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Systemic lupus erythematosus when taking Nucynta? *

  • female: 92.31 %
  • male: 7.69 %

What is the age of people who have Systemic lupus erythematosus when taking Nucynta? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 60 %
  • 50-59: 20 %
  • 60+: 20 %

What are other drugs people take besides Nucynta? *

  1. Humira: 8 people, 61.54%
  2. Zofran: 6 people, 46.15%
  3. Vitamin D: 6 people, 46.15%
  4. Vitamin B12: 6 people, 46.15%
  5. Meclizine: 5 people, 38.46%
  6. Zanaflex: 5 people, 38.46%
  7. Ambien: 5 people, 38.46%
  8. Rabeprazole: 5 people, 38.46%
  9. Delsym: 5 people, 38.46%
  10. Bentyl: 5 people, 38.46%

What are other side effects people have besides Systemic lupus erythematosus? *

  1. Weakness: 5 people, 38.46%
  2. Rhinorrhea (watery mucus discharge from the nose): 5 people, 38.46%
  3. Gastrointestinal Disorder (functional problems of gastrointestinal tract): 5 people, 38.46%
  4. Gait Disturbance: 5 people, 38.46%
  5. Head Injury: 5 people, 38.46%
  6. Herpes Zoster: 5 people, 38.46%
  7. Hypoaesthesia (reduced sense of touch or sensation): 5 people, 38.46%
  8. Infection: 5 people, 38.46%
  9. Ear Congestion: 5 people, 38.46%
  10. Memory Loss: 5 people, 38.46%

What are the existing conditions these people have? *

  1. Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 5 people, 38.46%
  2. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 15.38%
  3. High Blood Pressure: 2 people, 15.38%
  4. Type 1 Diabetes: 1 person, 7.69%
  5. Osteopenia (a condition where bone mineral density is lower than normal): 1 person, 7.69%
  6. Neuralgia (pain in one or more nerves): 1 person, 7.69%
  7. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 7.69%
  8. Migraine (headache): 1 person, 7.69%
  9. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 7.69%
  10. High Blood Cholesterol: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Nucynta and have Systemic lupus erythematosus?

- Check whether Systemic lupus erythematosus is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Nucynta:

Systemic lupus erythematosus treatments and more:

How severe was Systemic lupus erythematosus and when was it recovered:

Expand to all the drugs that have ingredients of tapentadol hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Nucynta:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Systemic lupus erythematosus:

Browse all the conditions that are associated with Systemic lupus erythematosus:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on tapentadol hydrochloride (the active ingredients of Nucynta) and Nucynta (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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