Nyquil and Confusional state - a phase IV clinical study of FDA data

Summary:

Confusional state is reported as a side effect among people who take Nyquil (acetaminophen / dextromethorphan / doxylamine / pseudoephedrine), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Xyrem, and have Depression.

The phase IV clinical study analyzes which people have Confusional state when taking Nyquil. It is created by eHealthMe based on reports of 2,013 people who have side effects when taking Nyquil from the FDA, and is updated regularly.

What is Nyquil?

Nyquil has active ingredients of acetaminophen / dextromethorphan / doxylamine / pseudoephedrine. It is often used in cold symptoms. eHealthMe is studying from 2,240 Nyquil users. Check the latest studies of Nyquil.

What is Confusional state?

Confusional state is found to be associated with 2,722 drugs and 3,320 conditions by eHealthMe. Check the latest studies of Confusional state.

On Jul, 21, 2026

2,013 people reported to have side effects when taking Nyquil.
Among them, 26 people (1.29%) have Confusional state.

Among these 26 people:

How long have people been on Nyquil when they have Confusional state? *

What is the gender of people who have Confusional state when taking Nyquil? *

female: 36 %
male: 64 %

What is the age of people who have Confusional state when taking Nyquil? *

What are other drugs people take besides Nyquil? *

What are other side effects people have besides Confusional state? *

Tremor (trembling or shaking movements in one or more parts of your body): 11 people, 42.31%
Hyperhidrosis (abnormally increased sweating): 8 people, 30.77%
Mydriasis (a dilation of the pupil): 6 people, 23.08%
Agitation (state of anxiety or nervous excitement): 6 people, 23.08%
Arrhythmias (irregular heartbeat): 6 people, 23.08%
Weakness: 5 people, 19.23%
Fatigue (feeling of tiredness): 5 people, 19.23%
Serotonin Syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time): 4 people, 15.38%
Nausea (feeling of having an urge to vomit): 4 people, 15.38%
Muscle Rigidity (muscle stiffness): 4 people, 15.38%

What are the existing conditions these people have? *

Depression: 4 people, 15.38%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 11.54%
Panic Disorder: 3 people, 11.54%
High Blood Cholesterol: 3 people, 11.54%
Nasopharyngitis (inflammation of the nasopharynx): 3 people, 11.54%
Nasal Congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels): 3 people, 11.54%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 11.54%
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve): 2 people, 7.69%
Back Pain: 2 people, 7.69%
Pollakiuria (abnormally frequent passage of relatively small quantities or urine): 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Nyquil and have Confusional state?

- Check whether Confusional state is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Nyquil:

Nyquil (2,240 reports)

Confusional state treatments and more:

Confusional state (182,510 reports)

How severe was Confusional state and when was it recovered:

Confusional state in Nyquil

Expand to all the drugs that have ingredients of acetaminophen / dextromethorphan / doxylamine / pseudoephedrine:

Confusional state and drugs with ingredients of acetaminophen / dextromethorphan / doxylamine / pseudoephedrine (19 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Nyquil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Confusional state:

Confusional state (2,722 drugs)

Browse all the conditions that are associated with Confusional state:

Confusional state (3,320 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen / dextromethorphan / doxylamine / pseudoephedrine (the active ingredients of Nyquil) and Nyquil (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.