Oxycodone and acetaminophen and Bipolar i disorder - a phase IV clinical study of FDA data

Summary:

Bipolar i disorder is reported as a side effect among people who take Oxycodone and acetaminophen (acetaminophen; oxycodone hydrochloride), especially for people who are female, 30-39 old, also take Prozac, and have Cataplexy.

The phase IV clinical study analyzes which people have Bipolar i disorder when taking Oxycodone and acetaminophen. It is created by eHealthMe based on reports of 13,404 people who have side effects when taking Oxycodone and acetaminophen from the FDA, and is updated regularly.

What is Oxycodone and acetaminophen?

Oxycodone and acetaminophen has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 14,467 Oxycodone and acetaminophen users. Check the latest studies of Oxycodone and acetaminophen.

What is Bipolar i disorder?

Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode) is found to be associated with 381 drugs and 831 conditions by eHealthMe. Check the latest studies of Bipolar i disorder.

On Jul, 26, 2026

13,404 people reported to have side effects when taking Oxycodone and acetaminophen.
Among them, 14 people (0.1%) have Bipolar i disorder.

Could Oxycodone and acetaminophen cause Bipolar i disorder?

Among these 14 people:

What is the gender of people who have Bipolar i disorder when taking Oxycodone and acetaminophen? *

female: 71.43 %
male: 28.57 %

What is the age of people who have Bipolar i disorder when taking Oxycodone and acetaminophen? *

What are other drugs people take besides Oxycodone and acetaminophen? *

What are other side effects people have besides Bipolar i disorder? *

Stress And Anxiety: 6 people, 42.86%
Drug Ineffective: 6 people, 42.86%
Injury: 6 people, 42.86%
Urination - Painful: 6 people, 42.86%
Hallucinations (sensations that appear real but are created by your mind): 6 people, 42.86%
Post-Traumatic Stress Disorder: 6 people, 42.86%
Nightmares (unpleasant dreams): 6 people, 42.86%
Drowsiness: 5 people, 35.71%
Bruxism (habitual grinding of the teeth, typically during sleep): 5 people, 35.71%
Dehydration (dryness resulting from the removal of water): 5 people, 35.71%

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 42.86%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 42.86%
Sleep Disorder: 2 people, 14.29%
Restless Leg Syndrome (a powerful urge to move your legs): 2 people, 14.29%
Oral Herpes (viral infection of mouth): 2 people, 14.29%
Hypersensitivity: 2 people, 14.29%
Headache (pain in head): 2 people, 14.29%
Depression: 2 people, 14.29%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 2 people, 14.29%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Oxycodone and acetaminophen and have Bipolar i disorder?

- Check whether Bipolar i disorder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Oxycodone and acetaminophen:

Oxycodone and acetaminophen (14,467 reports)

Bipolar i disorder treatments and more:

Bipolar i disorder (18,481 reports)

How severe was Bipolar i disorder and when was it recovered:

Bipolar i disorder in Oxycodone and acetaminophen

Expand to all the drugs that have ingredients of acetaminophen; oxycodone hydrochloride:

Bipolar i disorder and drugs with ingredients of acetaminophen; oxycodone hydrochloride (79 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Oxycodone and acetaminophen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Bipolar i disorder:

Bipolar i disorder (381 drugs)

Browse all the conditions that are associated with Bipolar i disorder:

Bipolar i disorder (831 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; oxycodone hydrochloride (the active ingredients of Oxycodone and acetaminophen) and Oxycodone and acetaminophen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.