Paroxetine hydrochloride and Hepatic function abnormal - a phase IV clinical study of FDA data

Summary:

Hepatic function abnormal is reported as a side effect among people who take Paroxetine hydrochloride (paroxetine hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Lamictal, and have Bipolar disorder.

The phase IV clinical study analyzes which people have Hepatic function abnormal when taking Paroxetine hydrochloride. It is created by eHealthMe based on reports of 9,481 people who have side effects when taking Paroxetine hydrochloride from the FDA, and is updated regularly.

What is Paroxetine hydrochloride?

Paroxetine hydrochloride has active ingredients of paroxetine hydrochloride. It is often used in depression. eHealthMe is studying from 10,426 Paroxetine hydrochloride users. Check the latest studies of Paroxetine hydrochloride.

What is Hepatic function abnormal?

Hepatic function abnormal is found to be associated with 1,440 drugs and 2,021 conditions by eHealthMe. Check the latest studies of Hepatic function abnormal.

On Jul, 29, 2026

9,481 people reported to have side effects when taking Paroxetine hydrochloride.
Among them, 33 people (0.35%) have Hepatic function abnormal.

Could Paroxetine hydrochloride cause Hepatic function abnormal?

Among these 33 people:

How long have people been on Paroxetine hydrochloride when they have Hepatic function abnormal? *

What is the gender of people who have Hepatic function abnormal when taking Paroxetine hydrochloride? *

female: 66.67 %
male: 33.33 %

What is the age of people who have Hepatic function abnormal when taking Paroxetine hydrochloride? *

What are other drugs people take besides Paroxetine hydrochloride? *

What are other side effects people have besides Hepatic function abnormal? *

Fever: 8 people, 24.24%
Alanine Aminotransferase Increased: 7 people, 21.21%
Gamma-Glutamyltransferase Increased: 6 people, 18.18%
Blood Lactate Dehydrogenase Increased: 5 people, 15.15%
Hepatic Enzyme Increased: 5 people, 15.15%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 5 people, 15.15%
Aspartate Aminotransferase Increased: 5 people, 15.15%
Drug-Induced Liver Injury (diseases of the liver that are caused by physician-prescribed medications): 4 people, 12.12%
Delirium (wild excitement): 4 people, 12.12%
Drug Eruption (adverse drug reaction of the skin): 4 people, 12.12%

What are the existing conditions these people have? *

Bipolar Disorder (mood disorder): 4 people, 12.12%
Panic Disorder: 3 people, 9.09%
Irritability: 3 people, 9.09%
Insomnia (sleeplessness): 3 people, 9.09%
Delirium (wild excitement): 3 people, 9.09%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 3 people, 9.09%
Depressed Mood: 3 people, 9.09%
Sleep Disorder: 2 people, 6.06%
Depression Suicidal (suicide depressive disorder): 1 person, 3.03%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 1 person, 3.03%

* Approximation only. Some reports may have incomplete information.

Do you take Paroxetine hydrochloride and have Hepatic function abnormal?

- Check whether Hepatic function abnormal is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Paroxetine hydrochloride:

Paroxetine hydrochloride (10,426 reports)

Browse all side effects of Paroxetine hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hepatic function abnormal:

Hepatic function abnormal (1,440 drugs)

Browse all the conditions that are associated with Hepatic function abnormal:

Hepatic function abnormal (2,021 conditions)

Related publications that referenced our studies

Coskun M, Adak I, Akaltun I, "Bilateral gynecomastia in a preadolescent boy while under treatment with methylphenidate and paroxetine", Journal of clinical psychopharmacology, 2014 Aug .
Coskun M, Adak I, Akaltun I, "Bilateral gynecomastia in a preadolescent boy while under treatment with methylphenidate and paroxetine", Journal of clinical psychopharmacology, 2014 Aug .

How the study uses the data?

The study uses data from the FDA. It is based on paroxetine hydrochloride (the active ingredients of Paroxetine hydrochloride) and Paroxetine hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.