Paxil and Localised osteoarthritis - a phase IV clinical study of FDA data

Summary:

Localised osteoarthritis is reported as a side effect among people who take Paxil (paroxetine hydrochloride), especially for people who are male, 60+ old, also take Vioxx, and have Glaucoma.

The phase IV clinical study analyzes which people have Localised osteoarthritis when taking Paxil. It is created by eHealthMe based on reports of 88,676 people who have side effects when taking Paxil from the FDA, and is updated regularly.

What is Paxil?

Paxil has active ingredients of paroxetine hydrochloride. It is often used in depression. eHealthMe is studying from 92,546 Paxil users. Check the latest studies of Paxil.

What is Localised osteoarthritis?

Localised osteoarthritis (infection of joint affects only single joint) is found to be associated with 101 drugs and 125 conditions by eHealthMe. Check the latest studies of Localised osteoarthritis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 29, 2026

88,676 people reported to have side effects when taking Paxil.
Among them, 21 people (0.02%) have Localised osteoarthritis.

Could Paxil cause Localised osteoarthritis?

Among these 21 people:

What is the gender of people who have Localised osteoarthritis when taking Paxil? *

female: 42.86 %
male: 57.14 %

What is the age of people who have Localised osteoarthritis when taking Paxil? *

What are other drugs people take besides Paxil? *

What are other side effects people have besides Localised osteoarthritis? *

Headache (pain in head): 14 people, 66.67%
Chronic Obstructive Airways Disease: 13 people, 61.90%
Osteoporosis (bones weak and more likely to break): 11 people, 52.38%
Diarrhea: 11 people, 52.38%
Liver Function Test Abnormal: 11 people, 52.38%
Abdominal Pain: 10 people, 47.62%
Cardiac Failure Congestive: 10 people, 47.62%
Anaemia (lack of blood): 9 people, 42.86%
Cellulitis (infection under the skin): 9 people, 42.86%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 9 people, 42.86%

What are the existing conditions these people have? *

High Blood Cholesterol: 9 people, 42.86%
Glaucoma (increased fluid pressure in the eye with vision loss): 9 people, 42.86%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 14.29%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 3 people, 14.29%
Oedema Peripheral (superficial swelling): 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

Do you take Paxil and have Localised osteoarthritis?

- Check whether Localised osteoarthritis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Paxil:

Paxil (92,546 reports)

Browse all side effects of Paxil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Localised osteoarthritis:

Localised osteoarthritis (101 drugs)

Browse all the conditions that are associated with Localised osteoarthritis:

Localised osteoarthritis (125 conditions)

Related publications that referenced our studies

Coskun M, Adak I, Akaltun I, "Bilateral gynecomastia in a preadolescent boy while under treatment with methylphenidate and paroxetine", Journal of clinical psychopharmacology, 2014 Aug .
Coskun M, Adak I, Akaltun I, "Bilateral gynecomastia in a preadolescent boy while under treatment with methylphenidate and paroxetine", Journal of clinical psychopharmacology, 2014 Aug .

How the study uses the data?

The study uses data from the FDA. It is based on paroxetine hydrochloride (the active ingredients of Paxil) and Paxil (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.