Pentasa and Osteoporosis - a phase IV clinical study of FDA data

Summary:

Osteoporosis is reported as a side effect among people who take Pentasa (mesalamine), especially for people who are female, 60+ old, have been taking the drug for 5 - 10 years also take Lisinopril, and have Osteopenia.

The phase IV clinical study analyzes which people have Osteoporosis when taking Pentasa. It is created by eHealthMe based on reports of 22,797 people who have side effects when taking Pentasa from the FDA, and is updated regularly.

What is Pentasa?

Pentasa has active ingredients of mesalamine. It is often used in crohn's disease. eHealthMe is studying from 23,326 Pentasa users. Check the latest studies of Pentasa.

What is Osteoporosis?

Osteoporosis (bones weak and more likely to break) is found to be associated with 1,806 drugs and 1,905 conditions by eHealthMe. Check the latest studies of Osteoporosis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Jul, 16, 2026

22,797 people reported to have side effects when taking Pentasa.
Among them, 69 people (0.3%) have Osteoporosis.

Among these 69 people:

How long have people been on Pentasa when they have Osteoporosis? *

What is the gender of people who have Osteoporosis when taking Pentasa? *

female: 81.97 %
male: 18.03 %

What is the age of people who have Osteoporosis when taking Pentasa? *

What are other drugs people take besides Pentasa? *

What are other side effects people have besides Osteoporosis? *

Pain: 26 people, 37.68%
High Blood Pressure: 26 people, 37.68%
Stress And Anxiety: 21 people, 30.43%
Fatigue (feeling of tiredness): 20 people, 28.99%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 20 people, 28.99%
Chest Pain: 20 people, 28.99%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 20 people, 28.99%
Dyspnea (difficult or laboured breathing): 19 people, 27.54%
Anaemia (lack of blood): 19 people, 27.54%
Diarrhea: 19 people, 27.54%

What are the existing conditions these people have? *

Osteopenia (a condition where bone mineral density is lower than normal): 19 people, 27.54%
Fever: 6 people, 8.70%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 3 people, 4.35%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 2.90%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 2 people, 2.90%
Depression: 2 people, 2.90%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 1 person, 1.45%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 1.45%
Cardiac Disorder: 1 person, 1.45%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 1 person, 1.45%

* Approximation only. Some reports may have incomplete information.

Do you take Pentasa and have Osteoporosis?

- Check whether Osteoporosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Pentasa:

Pentasa (23,326 reports)

Osteoporosis treatments and more:

Osteoporosis (290,735 reports)

Browse all side effects of Pentasa:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Osteoporosis:

Osteoporosis (1,806 drugs)

Browse all the conditions that are associated with Osteoporosis:

Osteoporosis (1,905 conditions)

Related publications that referenced our studies

Jacobsson H, Eriksen J, Karlén P, "Mesalazine-induced renal calculi", The American journal of case reports, 2015 Jan .
Hirschmann S, Gibel A, Tsvelikhovsky I, Lisker A, "Late-Onset Psychosis and Risedronate Treatment for Osteoporosis: A Case Report", Clinical schizophrenia & related psychoses, 2013 May .
Ko KD, Cho BL, "Risedronate-related Localized Amnesia in an Elderly Patient with Osteoporosis", Journal of the Korean Geriatrics Society, 2012 Dec .
Lee WY, Sun LM, Lin MC, Liang JA, Chang SN, Sung FC, Muo CH, Kao CH, "A higher dosage of oral alendronate will increase the subsequent cancer risk of osteoporosis patients in Taiwan: a population-based cohort study", PloS one, 2012 Dec .
Hirschmann S, Gibel A, Tsvelikhovsky I, Lisker A, "Late-Onset Psychosis and Risedronate Treatment for Osteoporosis: A Case Report", Clinical schizophrenia & related psychoses, 2013 May .
Jacobsson H, Eriksen J, Karlén P, "Mesalazine-induced renal calculi", The American journal of case reports, 2015 Jan .
Ko KD, Cho BL, "Risedronate-related Localized Amnesia in an Elderly Patient with Osteoporosis", Journal of the Korean Geriatrics Society, 2012 Dec .
Lee WY, Sun LM, Lin MC, Liang JA, Chang SN, Sung FC, Muo CH, Kao CH, "A higher dosage of oral alendronate will increase the subsequent cancer risk of osteoporosis patients in Taiwan: a population-based cohort study", PloS one, 2012 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on mesalamine (the active ingredients of Pentasa) and Pentasa (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.