Percocet and Toxic encephalopathy - a phase IV clinical study of FDA data

Summary:

Toxic encephalopathy is reported as a side effect among people who take Percocet (acetaminophen; oxycodone hydrochloride), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Dilaudid, and have On and off phenomenon.

The phase IV clinical study analyzes which people have Toxic encephalopathy when taking Percocet. It is created by eHealthMe based on reports of 116,194 people who have side effects when taking Percocet from the FDA, and is updated regularly.

What is Percocet?

Percocet has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 119,838 Percocet users. Check the latest studies of Percocet.

What is Toxic encephalopathy?

Toxic encephalopathy (a degenerative neurologic disorder caused by exposure to toxic substances) is found to be associated with 424 drugs and 616 conditions by eHealthMe. Check the latest studies of Toxic encephalopathy.

On Jul, 26, 2026

116,194 people reported to have side effects when taking Percocet.
Among them, 55 people (0.05%) have Toxic encephalopathy.

Could Percocet cause Toxic encephalopathy?

Among these 55 people:

How long have people been on Percocet when they have Toxic encephalopathy? *

What is the gender of people who have Toxic encephalopathy when taking Percocet? *

female: 26.42 %
male: 73.58 %

What is the age of people who have Toxic encephalopathy when taking Percocet? *

What are other drugs people take besides Percocet? *

What are other side effects people have besides Toxic encephalopathy? *

Pneumonia: 31 people, 56.36%
Memory Loss: 21 people, 38.18%
Confusional State: 15 people, 27.27%
Pain In Extremity: 14 people, 25.45%
Dehydration (dryness resulting from the removal of water): 14 people, 25.45%
Leukocytosis (increased white blood cells): 12 people, 21.82%
Fall: 12 people, 21.82%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 12 people, 21.82%
Stress And Anxiety: 12 people, 21.82%
Head Injury: 11 people, 20.00%

What are the existing conditions these people have? *

On And Off Phenomenon: 8 people, 14.55%
Metastases To Bone (cancer spreads to bone): 6 people, 10.91%
Metastases To Prostate (cancer spreads to prostate): 6 people, 10.91%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 10.91%
Parkinson's Disease: 5 people, 9.09%
Nausea (feeling of having an urge to vomit): 3 people, 5.45%
Pain In Extremity: 3 people, 5.45%
Trigeminal Neuralgia (a painful condition of the nerve responsible for most facial sensation): 3 people, 5.45%
Stress And Anxiety: 3 people, 5.45%
Prostate Cancer: 2 people, 3.64%

* Approximation only. Some reports may have incomplete information.

Do you take Percocet and have Toxic encephalopathy?

- Check whether Toxic encephalopathy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Percocet:

Percocet (119,838 reports)

Toxic encephalopathy treatments and more:

Toxic encephalopathy (4,868 reports)

How severe was Toxic encephalopathy and when was it recovered:

Toxic encephalopathy in Percocet

Expand to all the drugs that have ingredients of acetaminophen; oxycodone hydrochloride:

Toxic encephalopathy and drugs with ingredients of acetaminophen; oxycodone hydrochloride (53 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Percocet:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Toxic encephalopathy:

Toxic encephalopathy (424 drugs)

Browse all the conditions that are associated with Toxic encephalopathy:

Toxic encephalopathy (616 conditions)

Related publications that referenced our studies

Jeong SY, Jeon SJ, Kim YR, Choi SS, Kwak HS, "A Rare Case of Viagra Induced Toxic Encephalopathy", Investigative Magnetic Resonance Imaging, 2016 Sep .
Jeong SY, Jeon SJ, Kim YR, Choi SS, Kwak HS, "A Rare Case of Viagra Induced Toxic Encephalopathy", Investigative Magnetic Resonance Imaging, 2016 Sep .

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; oxycodone hydrochloride (the active ingredients of Percocet) and Percocet (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.