Coreg and Metaxalone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Coreg (carvedilol) and Metaxalone (metaxalone). Common drug interactions include nausea among females and lower gastrointestinal haemorrhage among males.

The phase IV clinical study analyzes what interactions people have when they take Coreg and Metaxalone. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Coreg?

Coreg has active ingredients of carvedilol. It is often used in high blood pressure. eHealthMe is studying from 49,583 Coreg users. Check the latest studies of Coreg.

What is Metaxalone?

Metaxalone has active ingredients of metaxalone. It is often used in back pain. eHealthMe is studying from 4,452 Metaxalone users. Check the latest studies of Metaxalone.

On Jul, 26, 2026

29 people who take Coreg and Metaxalone together, and have interactions are studied.

What are the common drug interactions of Coreg and Metaxalone, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Chronic kidney disease
Renal failure (kidney dysfunction)
Cardiac failure congestive
Confusional state
Nephrogenic anaemia (anaemia due to kidney disease)
Pneumonia
Renal impairment (severely reduced kidney function)
Abnormal loss of weight
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)

male:

Lower gastrointestinal haemorrhage (bleeding in the large intestine, rectum, or anus is called lower gi bleeding)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Adverse drug reaction
Arthralgia (joint pain)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Gait disturbance
Hypoaesthesia (reduced sense of touch or sensation)
Myalgia (muscle pain)
Nausea (feeling of having an urge to vomit)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

What are the common drug interactions of Coreg and Metaxalone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Acute myocardial infarction (acute heart attack)
Cardiac failure congestive
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Diastolic dysfunction
Pleural effusion (water on the lungs)
Abnormal dreams
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Pneumonia

50-59:

Nausea (feeling of having an urge to vomit)
Abdominal pain
Asthma
Chest pain
Confusional state
Dizziness
Dyspnoea (difficult or laboured respiration)
Facial spasm (involuntary muscle contractions face)
Fall
Fatigue (feeling of tiredness)

60+:

Lower gastrointestinal haemorrhage (bleeding in the large intestine, rectum, or anus is called lower gi bleeding)
Chronic kidney disease
Cystitis interstitial (unknown cause characterized by bladder pain)
Decreased appetite
Visual impairment
Abasia (inability to walk)
Abdominal pain upper
Adverse drug reaction
Arthralgia (joint pain)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)

What are the existing conditions these people have? *

Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 11 people, 37.93%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 10 people, 34.48%
Pain: 6 people, 20.69%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 17.24%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 13.79%
Cardiac Disorder: 3 people, 10.34%
Depression: 3 people, 10.34%
Diabetes: 3 people, 10.34%
Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 3 people, 10.34%
Fluid Retention (an abnormal accumulation of fluid in the blood): 2 people, 6.90%

* Approximation only. Some reports may have incomplete information.

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