Periactin and Depression - a phase IV clinical study of FDA data

Summary:

Depression is reported as a side effect among people who take Periactin (cyproheptadine hydrochloride), especially for people who are female, 10-19 old, have been taking the drug for 10+ years also take Prilosec, and have Pain.

The phase IV clinical study analyzes which people have Depression when taking Periactin. It is created by eHealthMe based on reports of 2,086 people who have side effects when taking Periactin from the FDA, and is updated regularly.

What is Periactin?

Periactin has active ingredients of cyproheptadine hydrochloride. It is often used in migraine. eHealthMe is studying from 2,214 Periactin users. Check the latest studies of Periactin.

What is Depression?

Depression is found to be associated with 3,168 drugs and 4,130 conditions by eHealthMe. Check the latest studies of Depression.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

2,086 people reported to have side effects when taking Periactin.
Among them, 31 people (1.49%) have Depression.

Among these 31 people:

How long have people been on Periactin when they have Depression? *

What is the gender of people who have Depression when taking Periactin? *

female: 77.42 %
male: 22.58 %

What is the age of people who have Depression when taking Periactin? *

What are other drugs people take besides Periactin? *

What are other side effects people have besides Depression? *

Suicidal Ideation: 8 people, 25.81%
Stress And Anxiety: 7 people, 22.58%
Fatigue (feeling of tiredness): 5 people, 16.13%
Insomnia (sleeplessness): 4 people, 12.90%
High Blood Pressure: 4 people, 12.90%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 12.90%
Pathological Gambling: 4 people, 12.90%
Abdominal Pain: 4 people, 12.90%
Suicide Attempt: 4 people, 12.90%
Dizziness: 4 people, 12.90%

What are the existing conditions these people have? *

Pain: 7 people, 22.58%
High Blood Pressure: 6 people, 19.35%
Cystic Fibrosis (disease of the secretary glands): 5 people, 16.13%
Stress And Anxiety: 4 people, 12.90%
Itching: 4 people, 12.90%
Restless Leg Syndrome (a powerful urge to move your legs): 4 people, 12.90%
Joint Pain: 4 people, 12.90%
Laryngitis (inflammation of the larynx): 4 people, 12.90%
Weakness: 4 people, 12.90%
Insomnia (sleeplessness): 3 people, 9.68%

* Approximation only. Some reports may have incomplete information.

Do you take Periactin and have Depression?

- Check whether Depression is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Periactin:

Periactin (2,214 reports)

Depression treatments and more:

Depression (652,162 reports)

Browse all side effects of Periactin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Depression:

Depression (3,168 drugs)

Browse all the conditions that are associated with Depression:

Depression (4,130 conditions)

Related publications that referenced our studies

Pang, T., & Gudi, A., "Chest pain following the use of fluvoxamine in depression", Proceedings of Singapore Healthcare, 2018 Jan .
Pang, T., & Gudi, A., "Chest pain following the use of fluvoxamine in depression", Proceedings of Singapore Healthcare, 2018 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on cyproheptadine hydrochloride (the active ingredients of Periactin) and Periactin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.