Pramine and Sinus bradycardia - a phase IV clinical study of FDA data

Summary:

Sinus bradycardia is reported as a side effect among people who take Pramine (imipramine hydrochloride), especially for people who are male, 60+ old, also take Gabapentin, and have Ill-defined disorder.

The phase IV clinical study analyzes which people have Sinus bradycardia when taking Pramine. It is created by eHealthMe based on reports of 7,187 people who have side effects when taking Pramine from the FDA, and is updated regularly.

What is Pramine?

Pramine has active ingredients of imipramine hydrochloride. eHealthMe is studying from 7,461 Pramine users. Check the latest studies of Pramine.

What is Sinus bradycardia?

Sinus bradycardia (an unusually slow heartbeat due to heart disease) is found to be associated with 897 drugs and 1,055 conditions by eHealthMe. Check the latest studies of Sinus bradycardia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

7,187 people reported to have side effects when taking Pramine.
Among them, 22 people (0.31%) have Sinus bradycardia.

Among these 22 people:

What is the gender of people who have Sinus bradycardia when taking Pramine? *

female: 33.33 %
male: 66.67 %

What is the age of people who have Sinus bradycardia when taking Pramine? *

What are other drugs people take besides Pramine? *

What are other side effects people have besides Sinus bradycardia? *

Dyspnea (difficult or laboured breathing): 9 people, 40.91%
Weakness: 8 people, 36.36%
Hypotension (abnormally low blood pressure): 8 people, 36.36%
Nausea (feeling of having an urge to vomit): 7 people, 31.82%
Bundle Branch Block Right (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the right ventricle): 7 people, 31.82%
Dizziness: 7 people, 31.82%
High Blood Pressure: 6 people, 27.27%
Blood Glucose Increased: 6 people, 27.27%
Fatigue (feeling of tiredness): 6 people, 27.27%
Myocardial Ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased): 5 people, 22.73%

What are the existing conditions these people have? *

Ill-Defined Disorder: 4 people, 18.18%
Dermatitis Diaper (diaper rash is a common form of inflamed skin): 3 people, 13.64%
Pain: 3 people, 13.64%
Depression: 3 people, 13.64%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 9.09%
Joint Pain: 2 people, 9.09%
Tremor (trembling or shaking movements in one or more parts of your body): 1 person, 4.55%
B-Cell Small Lymphocytic Lymphoma (blood cancer affecting b cells): 1 person, 4.55%
Cardiac Failure Congestive: 1 person, 4.55%
Chest Pain: 1 person, 4.55%

* Approximation only. Some reports may have incomplete information.

Do you take Pramine and have Sinus bradycardia?

- Check whether Sinus bradycardia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Pramine:

Pramine (7,461 reports)

Browse all side effects of Pramine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sinus bradycardia:

Sinus bradycardia (897 drugs)

Browse all the conditions that are associated with Sinus bradycardia:

Sinus bradycardia (1,055 conditions)

Related publications that referenced our studies

Yaylaci S, Kocayigit I, Genc A, Tamer A, Gunduz H, "Sinus bradycardia caused by flurbiprofen intoxication", Nigerian Journal of Cardiology, 2015 Jan .
Yaylaci S, Kocayigit I, Genc A, Tamer A, Gunduz H, "Sinus bradycardia caused by flurbiprofen intoxication", Nigerian Journal of Cardiology, 2015 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on imipramine hydrochloride (the active ingredients of Pramine) and Pramine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.