Prednisolone and Brain death - a phase IV clinical study of FDA data

Summary:

Brain death is reported as a side effect among people who take Prednisolone (prednisolone), especially for people who are male, 40-49 old, have been taking the drug for 2 - 5 years also take Methotrexate, and have Bone marrow conditioning regimen.

The study is created by eHealthMe based on reports of 211,370 people who have side effects when taking Prednisolone from the FDA, and is updated regularly.

What is Prednisolone?

Prednisolone has active ingredients of prednisolone. It is often used in rheumatoid arthritis. eHealthMe is studying from 212,675 Prednisolone users. Check the latest studies of Prednisolone.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 23, 2026

211,370 people reported to have side effects when taking Prednisolone.
Among them, 38 people (0.02%) died.

Among these 38 people:

How long have people been on Prednisolone when they died? *

What is the gender of people who died when taking Prednisolone? *

female: 48.65 %
male: 51.35 %

What is the age of people who died when taking Prednisolone? *

What are other drugs people take besides Prednisolone? *

What are other side effects people have before they died? *

Brain Oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain): 9 people, 23.68%
Consciousness - Decreased: 8 people, 21.05%
Nausea And Vomiting: 7 people, 18.42%
Cerebral Infarction (less blood supply to brain resulting tissue damage): 7 people, 18.42%
Breathing - Slowed Or Stopped: 7 people, 18.42%
Headache (pain in head): 6 people, 15.79%
Loss Of Consciousness: 6 people, 15.79%
Ards (Acute Respiratory Distress Syndrome) (sudden failure of the respiratory (breathing) system): 6 people, 15.79%
Cardiac Arrest: 5 people, 13.16%
Brain Herniation (brain herniation is a potentially deadly side effect of very high intracranial pressure that occurs when a part of the brain is squeezed across structures within the skull): 4 people, 10.53%

What are the existing conditions these people have? *

Sedation: 2 people, 5.26%
Graft Versus Host Disease In Skin (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the skin): 2 people, 5.26%
Dermatomyositis (inflammation of the skin and underlying muscle tissue, typically occurring as an autoimmune condition or associated with internal cancer): 2 people, 5.26%
Bone Marrow Conditioning Regimen: 2 people, 5.26%
Wound Complication: 1 person, 2.63%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 1 person, 2.63%
Type 1 Diabetes: 1 person, 2.63%
Systemic Mycosis (fungal infections of the body): 1 person, 2.63%
Pneumonia Aspergillus (invasive type is a serious infection with pneumonia that can spread to other parts of the body): 1 person, 2.63%
Leukopenia (less number of white blood cells in blood): 1 person, 2.63%

* Approximation only. Some reports may have incomplete information.

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Prednisolone:

Prednisolone (212,675 reports)

Expand to all the drugs that have ingredients of prednisolone:

Brain death and drugs with ingredients of prednisolone (38 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Prednisolone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Brain death:

Brain death (315 drugs)

Browse all the conditions that are associated with Brain death:

Brain death (489 conditions)

Related publications that referenced our studies

Abdullah, D., Mohamed, A. M. F. S., & Liew, A. K. C., "Dentine hypersensitivity-like tooth pain associated with the use of high-dose steroid therapy", Journal of conservative dentistry: JCD, 2018 Jan .
Abdullah, D., Mohamed, A. M. F. S., & Liew, A. K. C., "Dentine hypersensitivity-like tooth pain associated with the use of high-dose steroid therapy", Journal of conservative dentistry: JCD, 2018 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on prednisolone (the active ingredients of Prednisolone) and Prednisolone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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