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Pregabalin and Freezing phenomenon - a phase IV clinical study of FDA data

Summary:

Freezing phenomenon is reported as a side effect among people who take Pregabalin (pregabalin), especially for people who are female, 60+ old, have been taking the drug for 1 - 2 years also take Mirtazapine, and have Parkinson's disease.

The phase IV clinical study analyzes which people have Freezing phenomenon when taking Pregabalin. It is created by eHealthMe based on reports of 73,056 people who have side effects when taking Pregabalin from the FDA, and is updated regularly.

What is Pregabalin?

Pregabalin has active ingredients of pregabalin. It is often used in fibromyalgia. eHealthMe is studying from 74,069 Pregabalin users. Check the latest studies of Pregabalin.

What is Freezing phenomenon?

Freezing phenomenon is found to be associated with 208 drugs and 231 conditions by eHealthMe. Check the latest studies of Freezing phenomenon.

On Jul, 23, 2026

73,056 people reported to have side effects when taking Pregabalin.
Among them, 27 people (0.04%) have Freezing phenomenon.

Could Pregabalin cause Freezing phenomenon?

Among these 27 people:

How long have people been on Pregabalin when they have Freezing phenomenon? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 100 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Freezing phenomenon when taking Pregabalin? *

  • female: 74.07 %
  • male: 25.93 %

What is the age of people who have Freezing phenomenon when taking Pregabalin? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 5.56 %
  • 40-49: 0.0 %
  • 50-59: 27.78 %
  • 60+: 66.67 %

What are other drugs people take besides Pregabalin? *

  1. Mirtazapine: 13 people, 48.15%
  2. Amantadine: 10 people, 37.04%
  3. Sinemet: 10 people, 37.04%
  4. Senna: 9 people, 33.33%
  5. Azilect: 8 people, 29.63%
  6. Movicol: 7 people, 25.93%
  7. Vitamin B12: 6 people, 22.22%
  8. Calcium Carbonate: 6 people, 22.22%
  9. Lorazepam: 5 people, 18.52%
  10. Olanzapine: 5 people, 18.52%

What are other side effects people have besides Freezing phenomenon? *

  1. Mobility Decreased (ability to move is reduced): 15 people, 55.56%
  2. On And Off Phenomenon: 15 people, 55.56%
  3. Bradykinesia (decreased bodily movement. it is associated with basal ganglia diseases): 13 people, 48.15%
  4. Fall: 11 people, 40.74%
  5. Stress And Anxiety: 9 people, 33.33%
  6. Pain In Extremity: 8 people, 29.63%
  7. Dyskinesia (abnormality or impairment of voluntary movement): 8 people, 29.63%
  8. Tremor (trembling or shaking movements in one or more parts of your body): 8 people, 29.63%
  9. Muscle Rigidity (muscle stiffness): 8 people, 29.63%
  10. Parkinson's Disease: 8 people, 29.63%

What are the existing conditions these people have? *

  1. Parkinson's Disease: 21 people, 77.78%
  2. Hallucinations (sensations that appear real but are created by your mind): 2 people, 7.41%
  3. Abnormal Faeces (abnormal stool): 2 people, 7.41%
  4. Vitamin D Decreased: 1 person, 3.70%
  5. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 3.70%
  6. Psychotic Disorder: 1 person, 3.70%
  7. Polyneuropathy (neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously): 1 person, 3.70%
  8. Neuropathy Peripheral (surface nerve damage): 1 person, 3.70%
  9. Immunodeficiency Common Variable: 1 person, 3.70%
  10. High Blood Cholesterol: 1 person, 3.70%

* Approximation only. Some reports may have incomplete information.

Do you take Pregabalin and have Freezing phenomenon?

- Check whether Freezing phenomenon is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Pregabalin:

Freezing phenomenon treatments and more:

How severe was Freezing phenomenon and when was it recovered:

Expand to all the drugs that have ingredients of pregabalin:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Pregabalin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Freezing phenomenon:

Browse all the conditions that are associated with Freezing phenomenon:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on pregabalin (the active ingredients of Pregabalin) and Pregabalin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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