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Premarin and Hyperparathyroidism secondary - a phase IV clinical study of FDA data

Summary:

Hyperparathyroidism secondary is reported as a side effect among people who take Premarin (estrogens, conjugated), especially for people who are female, 60+ old, have been taking the drug for 5 - 10 years also take Nexium, and have Gastroesophageal reflux disease.

The phase IV clinical study analyzes which people have Hyperparathyroidism secondary when taking Premarin. It is created by eHealthMe based on reports of 98,531 people who have side effects when taking Premarin from the FDA, and is updated regularly.

What is Premarin?

Premarin has active ingredients of estrogens, conjugated. It is often used in hormone replacement therapy. eHealthMe is studying from 99,630 Premarin users. Check the latest studies of Premarin.

What is Hyperparathyroidism secondary?

Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary) is found to be associated with 697 drugs and 461 conditions by eHealthMe. Check the latest studies of Hyperparathyroidism secondary.

On Aug, 03, 2026

98,531 people reported to have side effects when taking Premarin.
Among them, 82 people (0.08%) have Hyperparathyroidism secondary.

Could Premarin cause Hyperparathyroidism secondary?

Among these 82 people:

How long have people been on Premarin when they have Hyperparathyroidism secondary? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 9.09 %
  • 6 - 12 months: 4.55 %
  • 1 - 2 years: 4.55 %
  • 2 - 5 years: 4.55 %
  • 5 - 10 years: 59.09 %
  • 10+ years: 18.18 %

What is the gender of people who have Hyperparathyroidism secondary when taking Premarin? *

  • female: 96.15 %
  • male: 3.85 %

What is the age of people who have Hyperparathyroidism secondary when taking Premarin? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 4.23 %
  • 50-59: 29.58 %
  • 60+: 66.2 %

What are other drugs people take besides Premarin? *

  1. Nexium: 67 people, 81.71%
  2. Prilosec: 46 people, 56.10%
  3. Prevacid: 35 people, 42.68%
  4. Amlodipine: 26 people, 31.71%
  5. Lipitor: 24 people, 29.27%
  6. Protonix: 24 people, 29.27%
  7. Tylenol: 24 people, 29.27%
  8. Prilosec Otc: 22 people, 26.83%
  9. Crestor: 21 people, 25.61%
  10. Nexium 24hr: 20 people, 24.39%

What are other side effects people have besides Hyperparathyroidism secondary? *

  1. Chronic Kidney Disease: 79 people, 96.34%
  2. Acute Kidney Failure: 59 people, 71.95%
  3. Nephrogenic Anaemia (anaemia due to kidney disease): 50 people, 60.98%
  4. Renal Injury (kidney injury): 12 people, 14.63%
  5. Interstitial Nephritis (inflammation of the kidney): 9 people, 10.98%
  6. Renal Impairment (severely reduced kidney function): 8 people, 9.76%
  7. Renal Tubular Necrosis (death of kidney tubules): 6 people, 7.32%
  8. Depression: 6 people, 7.32%
  9. Renal Disorder (kidney disease): 4 people, 4.88%
  10. Death: 4 people, 4.88%

What are the existing conditions these people have? *

  1. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 65 people, 79.27%
  2. Pain: 47 people, 57.32%
  3. High Blood Cholesterol: 42 people, 51.22%
  4. High Blood Pressure: 39 people, 47.56%
  5. Depression: 26 people, 31.71%
  6. Stress And Anxiety: 20 people, 24.39%
  7. Diabetes: 19 people, 23.17%
  8. Multiple Allergies (allergy to multiple agents): 17 people, 20.73%
  9. Blood Pressure Abnormal: 15 people, 18.29%
  10. Infection: 14 people, 17.07%

* Approximation only. Some reports may have incomplete information.

Do you take Premarin and have Hyperparathyroidism secondary?

- Check whether Hyperparathyroidism secondary is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Premarin:

Hyperparathyroidism secondary treatments and more:

How severe was Hyperparathyroidism secondary and when was it recovered:

Expand to all the drugs that have ingredients of estrogens, conjugated:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Premarin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperparathyroidism secondary:

Browse all the conditions that are associated with Hyperparathyroidism secondary:

How the study uses the data?

The study uses data from the FDA. It is based on estrogens, conjugated (the active ingredients of Premarin) and Premarin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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